| pubmed-article:9545575 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0061472 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:9545575 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9545575 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9545575 | pubmed:dateCreated | 1998-5-13 | lld:pubmed |
| pubmed-article:9545575 | pubmed:abstractText | The mechanism of the inhibitory effect of imipramine, a lipophilic organic cation on the Na+-dependent transport of L-glutamic acid across intestinal brush-border membrane was investigated. The uptake of L-glutamic acid by intestinal brush-border membrane vesicles was dependent on the concentration of Na+. Fitting of the uptake data in the presence of various concentrations of Na+ using Hill equation yielded a Hill coefficient of 2.18. This result suggest that the carrier system of L-glutamic acid has at least two sites for Na+-binding. By the analysis of double reciprocal plot and Dixon-type plot, it was found that imipramine inhibits the transport of L-glutamic acid by interacting competitively with the binding sites of Na+, but not inhibit L-glutamic acid binding site. Moreover, the effect of imipramine on the transport of L-alanine and D-glucose which are co-transported with only one Na+ molecule was also suggestive of interaction with the Na+-binding sites on the carrier. These results indicate that the mechanism of the inhibitory effect of imipramine on the Na+-dependent carrier systems is common for all systems regardless of the stoichiometry or substrates. | lld:pubmed |
| pubmed-article:9545575 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9545575 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9545575 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9545575 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9545575 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:9545575 | pubmed:author | pubmed-author:KatoMM | lld:pubmed |
| pubmed-article:9545575 | pubmed:author | pubmed-author:KobayashiMM | lld:pubmed |
| pubmed-article:9545575 | pubmed:author | pubmed-author:MiyazakiKK | lld:pubmed |
| pubmed-article:9545575 | pubmed:author | pubmed-author:SugawaraMM | lld:pubmed |
| pubmed-article:9545575 | pubmed:author | pubmed-author:IsekiKK | lld:pubmed |
| pubmed-article:9545575 | pubmed:copyrightInfo | Copyright 1998 Elsevier Science B.V. | lld:pubmed |
| pubmed-article:9545575 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9545575 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9545575 | pubmed:volume | 1370 | lld:pubmed |
| pubmed-article:9545575 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9545575 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9545575 | pubmed:pagination | 252-8 | lld:pubmed |
| pubmed-article:9545575 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
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| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:meshHeading | pubmed-meshheading:9545575-... | lld:pubmed |
| pubmed-article:9545575 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9545575 | pubmed:articleTitle | Mechanism of the inhibitory effect of imipramine on the Na+-dependent transport of L-glutamic acid in rat intestinal brush-border membrane. | lld:pubmed |
| pubmed-article:9545575 | pubmed:affiliation | Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University, Sapporo 060, Japan. | lld:pubmed |
| pubmed-article:9545575 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9545575 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9545575 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
