| pubmed-article:9541461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0026032 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0102137 | lld:lifeskim |
| pubmed-article:9541461 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9541461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9541461 | pubmed:dateCreated | 1998-5-26 | lld:pubmed |
| pubmed-article:9541461 | pubmed:abstractText | Respiratory infectious diseases are an important cause of economic losses to the cattle industry. There is a need for an effective, easy to administer vaccine to the critical bacterial pathogens that cause pneumonia in cattle. An orally administered vaccine could be given to a large number of animals without significant stress to the animals and with minimal labor. The purpose of this study was to determine whether the oral administration of a model antigen (ovalbumin) in alginate microspheres could induce pulmonary immunity in cattle. Calves were vaccinated orally with ovalbumin (OVA) following either a subcutaneous (s.c.) or oral priming dose of OVA. Calves primed and boostered by oral administration (oral/oral) of OVA encapsulated in alginate microparticles had increased numbers of antigen-specific IgA ASCs (ASCs) in bronchoalveolar lavage (BAL) fluids. Calves that received a s.c. priming followed by an oral booster inoculation (s.c./oral) of OVA in alginate microspheres had a greater number of anti-OVA IgA, IgG1 and IgG2 ASCs in BALF. S.c./oral calves also had increased numbers of anti-OVA IgG1 ASCs in peripheral blood whereas oral/oral calves had none. S.c./oral calves had increased anti-OVA IgG1, IgG2, and IgA titers in BALF, and IgG1 and IgG2 in serum compared to both oral/oral and sham vaccinated calves. These results indicate that oral administration of antigen encapsulated in alginate microspheres results in a mucosal immune response in the respiratory tract of cattle. Furthermore, s.c. priming both enhanced the IgA response and stimulated an IgG1 and IgG2 response not seen in oral/oral calves. The difference in antibody isotype results suggest that design of the vaccination protocol can direct antibody responses as needed for a specific immunization program. | lld:pubmed |
| pubmed-article:9541461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9541461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9541461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9541461 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9541461 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:ParkHH | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:ParkKK | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:BorioNN | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:WandAA | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:TorregrosaSS | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:HogenEschHH | lld:pubmed |
| pubmed-article:9541461 | pubmed:author | pubmed-author:BowersockT... | lld:pubmed |
| pubmed-article:9541461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9541461 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:9541461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9541461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9541461 | pubmed:pagination | 37-43 | lld:pubmed |
| pubmed-article:9541461 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:meshHeading | pubmed-meshheading:9541461-... | lld:pubmed |
| pubmed-article:9541461 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9541461 | pubmed:articleTitle | Induction of pulmonary immunity in cattle by oral administration of ovalbumin in alginate microspheres. | lld:pubmed |
| pubmed-article:9541461 | pubmed:affiliation | Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN 47907-1243, USA. | lld:pubmed |
| pubmed-article:9541461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9541461 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9541461 | lld:pubmed |
