Linked Life Data

9541116

Source:http://linkedlifedata.com/resource/pubmed/id/9541116

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pubmed-article:9541116pubmed:abstractTextWe report on pancreatic exocrine dysfunction in families that have the mitochondrial tRNA(Leu)(UUR) gene mutation. These families exhibited maternally inherited diabetes mellitus (DM) and an A to G substitution at nt 3243 of the mitochondrial tRNA(Leu)(UUR) gene (A3243G mutation). Pancreatic necropsy samples from one proband showed accumulation of degenerated mitochondria in pancreatic acinar cells. Pancreatic exocrine dysfunction was recognised by a functional pancreatic study. This study indicates that exocrine pancreatic dysfunction may be associated with the A3243G mutation.lld:pubmed
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pubmed-article:9541116pubmed:articleTitlePancreatic exocrine dysfunction associated with mitochondrial tRNA(Leu)(UUR) mutation.lld:pubmed
pubmed-article:9541116pubmed:affiliationDepartment of Psychiatry, Yokohama City University School of Medicine, Kanagawa, Japan.lld:pubmed
pubmed-article:9541116pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9541116pubmed:publicationTypeCase Reportslld:pubmed
pubmed-article:9541116pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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