| pubmed-article:9530210 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0001047 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0018850 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0243043 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:9530210 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9530210 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:9530210 | pubmed:dateCreated | 1998-4-14 | lld:pubmed |
| pubmed-article:9530210 | pubmed:abstractText | Increased synthesis of stress proteins may enhance myocardial viability during periods of low oxygen delivery. Our purpose was to determine if the oxidative stress protein heme oxygenase-1 [heat stress protein 32 (HSP 32)] was induced in hypoxic cardiomyocytes and whether this induction might be mediated by a redox-sensitive mechanism. Primary rat neonatal cardiomyocytes, cultured to express a tissuelike phenotype, responded to 12 h of hypoxia (< 0.5% ambient oxygen) with an approximately fivefold (range 3- to 7.5-fold; P < 0.05) increase in HSP 32 mRNA and a threefold (P < 0.05) increase in HSP 32 protein content. Exposure to 80 microM H2O2 for 3 h increased HSP 32 mRNA content to a similar extent. Expression of heme oxygenase-2 mRNA was unaffected by H2O2 or hypoxic treatments. Inclusion of 20 mM N-acetyl-L-cysteine in the medium during hypoxia reduced the increase in HSP 32 mRNA and protein expression by 25.50% compared with hypoxia alone. The data suggest that induction of HSP 32 protein may lead to an improved antioxidant defense in cardiomyocytes during hypoxia and that a redox-sensitive pathway mediates at least a portion of the hypoxic induction of the HSP 32 gene. | lld:pubmed |
| pubmed-article:9530210 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9530210 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530210 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9530210 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9530210 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9530210 | pubmed:author | pubmed-author:EssigD ADA | lld:pubmed |
| pubmed-article:9530210 | pubmed:author | pubmed-author:BorgerD RDR | lld:pubmed |
| pubmed-article:9530210 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9530210 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9530210 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9530210 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9530210 | pubmed:pagination | H965-73 | lld:pubmed |
| pubmed-article:9530210 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:meshHeading | pubmed-meshheading:9530210-... | lld:pubmed |
| pubmed-article:9530210 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9530210 | pubmed:articleTitle | Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with N-acetyl-L-cysteine. | lld:pubmed |
| pubmed-article:9530210 | pubmed:affiliation | Department of Exercise Science, University of South Carolina, Columbia 29208, USA. | lld:pubmed |
| pubmed-article:9530210 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9530210 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9530210 | lld:pubmed |
