pubmed-article:9499028 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C0178774 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C0017279 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:9499028 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:9499028 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:9499028 | pubmed:dateCreated | 1998-3-12 | lld:pubmed |
pubmed-article:9499028 | pubmed:abstractText | Previous studies have shown that in addition to its function in specific RNA encapsidation, the human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) is required for efficient virus particle assembly. However, the mechanism by which NC facilitates the assembly process is not clearly established. Formally, NC could act by constraining the Pr559gag polyprotein into an assembly-competent conformation or by masking residues which block the assembly process. Alternatively, the capacity of NC to bind RNA or make interprotein contacts might affect particle assembly. To examine its role in the assembly process, we replaced the NC domain in Pr55gag with polypeptide domains of known function, and the chimeric proteins were analyzed for their abilities to direct the release of virus-like particles. Our results indicate that NC does not mask inhibitory domains and does not act passively, by simply providing a stable folded monomeric structure. However, replacement of NC by polypeptides which form interprotein contacts permitted efficient virus particle assembly and release, even when RNA was not detected in the particles. These results suggest that formation of interprotein contacts by NC is essential to the normal HIV-1 assembly process. | lld:pubmed |
pubmed-article:9499028 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:language | eng | lld:pubmed |
pubmed-article:9499028 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9499028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9499028 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9499028 | pubmed:month | Mar | lld:pubmed |
pubmed-article:9499028 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:9499028 | pubmed:author | pubmed-author:LousII | lld:pubmed |
pubmed-article:9499028 | pubmed:author | pubmed-author:ZhangYY | lld:pubmed |
pubmed-article:9499028 | pubmed:author | pubmed-author:QianHH | lld:pubmed |
pubmed-article:9499028 | pubmed:author | pubmed-author:BarklisEE | lld:pubmed |
pubmed-article:9499028 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9499028 | pubmed:volume | 72 | lld:pubmed |
pubmed-article:9499028 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9499028 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9499028 | pubmed:pagination | 1782-9 | lld:pubmed |
pubmed-article:9499028 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:meshHeading | pubmed-meshheading:9499028-... | lld:pubmed |
pubmed-article:9499028 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9499028 | pubmed:articleTitle | Analysis of the assembly function of the human immunodeficiency virus type 1 gag protein nucleocapsid domain. | lld:pubmed |
pubmed-article:9499028 | pubmed:affiliation | Vollum Institute for Advanced Biomedical Research and Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201-3098, USA. | lld:pubmed |
pubmed-article:9499028 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9499028 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9499028 | lld:pubmed |