| pubmed-article:9482660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9482660 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:9482660 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9482660 | lifeskim:mentions | umls-concept:C1565114 | lld:lifeskim |
| pubmed-article:9482660 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9482660 | pubmed:dateCreated | 1998-3-30 | lld:pubmed |
| pubmed-article:9482660 | pubmed:abstractText | Many vertebrate cells are resistant to apoptotic stimuli, whose variety and the mechanisms involved are not fully understood. Endothelin-1 is an endothelium-derived vasoactive peptide that mediates many physiological functions, such as vasoconstriction and cell proliferation. Deregulated expression of c-Myc induces apoptosis in serum-deprived fibroblasts. Using a panel of isogenic fibroblast cell lines with differential c-myc expression levels, we demonstrate that low doses of endothelin-1 protect fibroblasts against serum deprivation-induced apoptosis, which occurs through a c-Myc-dependent process. The endothelin-1-induced cell survival was mediated by the ET(A) receptor and was not linked to the ability of endothelin-1 to induce cell proliferation. The survival function of endothelin-1 was abrogated by inhibiting the mitogen-activated protein kinase pathway. These results demonstrate a hitherto unappreciated role of endothelin-1 as a potent survival factor for c-Myc-dependent apoptosis, a process mediated by the ET(A) receptor and the mitogen-activated protein kinase pathway. | lld:pubmed |
| pubmed-article:9482660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9482660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9482660 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9482660 | pubmed:issn | 0888-8809 | lld:pubmed |
| pubmed-article:9482660 | pubmed:author | pubmed-author:HirataYY | lld:pubmed |
| pubmed-article:9482660 | pubmed:author | pubmed-author:ShichiriMM | lld:pubmed |
| pubmed-article:9482660 | pubmed:author | pubmed-author:MarumoFF | lld:pubmed |
| pubmed-article:9482660 | pubmed:author | pubmed-author:SedivyJ MJM | lld:pubmed |
| pubmed-article:9482660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9482660 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9482660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9482660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9482660 | pubmed:pagination | 172-80 | lld:pubmed |
| pubmed-article:9482660 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:meshHeading | pubmed-meshheading:9482660-... | lld:pubmed |
| pubmed-article:9482660 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9482660 | pubmed:articleTitle | Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis. | lld:pubmed |
| pubmed-article:9482660 | pubmed:affiliation | Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan. mshichiri.med2@med.tmd.ac.jp | lld:pubmed |
| pubmed-article:9482660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9482660 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9482660 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9482660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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