| pubmed-article:9472936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9472936 | lifeskim:mentions | umls-concept:C0013590 | lld:lifeskim |
| pubmed-article:9472936 | lifeskim:mentions | umls-concept:C0021359 | lld:lifeskim |
| pubmed-article:9472936 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9472936 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9472936 | lifeskim:mentions | umls-concept:C1450990 | lld:lifeskim |
| pubmed-article:9472936 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9472936 | pubmed:dateCreated | 1998-3-10 | lld:pubmed |
| pubmed-article:9472936 | pubmed:abstractText | Population control has become a major problem in many wildlife species. Fertility control through immunocontraception has been proposed as a method for reducing population size. We have tested the concept that immunocontraception can be achieved with a recombinant ectromelia virus expressing an ovary-specific antigen, the mouse zona pellucida 3 (ZP3) glycoprotein. Female mice infected with the recombinant virus produced autoimmune antibodies against ZP3 and were infertile for 5-9 mo after infection. For almost half the infertile mice, immunity to ZP3 was associated with a disruption of ovarian follicular development and the depletion of mature follicles without observable oophoritis. Mice returned to fertility as the anti-ZP3 antibody level in the serum decreased. Reinfection of the mice with the recombinant virus boosted the anti-ZP3 response and restored infertility. | lld:pubmed |
| pubmed-article:9472936 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9472936 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9472936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9472936 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9472936 | pubmed:issn | 0006-3363 | lld:pubmed |
| pubmed-article:9472936 | pubmed:author | pubmed-author:RamshawI AIA | lld:pubmed |
| pubmed-article:9472936 | pubmed:author | pubmed-author:JacksonR JRJ | lld:pubmed |
| pubmed-article:9472936 | pubmed:author | pubmed-author:MaguireD JDJ | lld:pubmed |
| pubmed-article:9472936 | pubmed:author | pubmed-author:HindsL ALA | lld:pubmed |
| pubmed-article:9472936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9472936 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:9472936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9472936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9472936 | pubmed:pagination | 152-9 | lld:pubmed |
| pubmed-article:9472936 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
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| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
| pubmed-article:9472936 | pubmed:meshHeading | pubmed-meshheading:9472936-... | lld:pubmed |
| pubmed-article:9472936 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9472936 | pubmed:articleTitle | Infertility in mice induced by a recombinant ectromelia virus expressing mouse zona pellucida glycoprotein 3. | lld:pubmed |
| pubmed-article:9472936 | pubmed:affiliation | Commonwealth Scientific Industrial Research Organisation, Division of Wildlife and Ecology, Australian National University, Canberra, ACT. r.jackson@dwe.csiro.au | lld:pubmed |
| pubmed-article:9472936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9472936 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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