| pubmed-article:9469647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0011991 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0043047 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C0123931 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C1456501 | lld:lifeskim |
| pubmed-article:9469647 | lifeskim:mentions | umls-concept:C2347946 | lld:lifeskim |
| pubmed-article:9469647 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9469647 | pubmed:dateCreated | 1998-3-24 | lld:pubmed |
| pubmed-article:9469647 | pubmed:abstractText | The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 (PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms. | lld:pubmed |
| pubmed-article:9469647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9469647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9469647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9469647 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9469647 | pubmed:issn | 0021-5198 | lld:pubmed |
| pubmed-article:9469647 | pubmed:author | pubmed-author:HayakawaTT | lld:pubmed |
| pubmed-article:9469647 | pubmed:author | pubmed-author:KamatakiTT | lld:pubmed |
| pubmed-article:9469647 | pubmed:author | pubmed-author:KomatsuYY | lld:pubmed |
| pubmed-article:9469647 | pubmed:author | pubmed-author:KaseYY | lld:pubmed |
| pubmed-article:9469647 | pubmed:author | pubmed-author:AburadaMM | lld:pubmed |
| pubmed-article:9469647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9469647 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:9469647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9469647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9469647 | pubmed:pagination | 407-13 | lld:pubmed |
| pubmed-article:9469647 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:meshHeading | pubmed-meshheading:9469647-... | lld:pubmed |
| pubmed-article:9469647 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9469647 | pubmed:articleTitle | Preventive effects of Hange-shashin-to on irinotecan hydrochloride-caused diarrhea and its relevance to the colonic prostaglandin E2 and water absorption in the rat. | lld:pubmed |
| pubmed-article:9469647 | pubmed:affiliation | Central Research Laboratories, Tsumura & Co., Inashiki-gun, Ibaraki, Japan. | lld:pubmed |
| pubmed-article:9469647 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9469647 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9469647 | lld:pubmed |
