| pubmed-article:9465054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9465054 | lifeskim:mentions | umls-concept:C0150369 | lld:lifeskim |
| pubmed-article:9465054 | lifeskim:mentions | umls-concept:C0242506 | lld:lifeskim |
| pubmed-article:9465054 | lifeskim:mentions | umls-concept:C0872367 | lld:lifeskim |
| pubmed-article:9465054 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9465054 | pubmed:dateCreated | 1998-3-19 | lld:pubmed |
| pubmed-article:9465054 | pubmed:abstractText | A recently developed, real-time spectroscopic technique, burst-integrated fluorescence lifetime (BIFL), is shown to be well suited for monitoring the individual molecular conformational dynamics of a single molecule diffusing through the microscopic, open measurement volume (approximately 10 fl) of a confocal epi-illuminated set-up. In a highly diluted aqueous solution of 20-mer oligonucleotide strand of DNA duplex labeled with the environment-sensitive fluorescent dye tetramethylrhodamine (TMR), fluorescence bursts indicating traces of individual molecules are registered and further subjected to selective burst analysis. The two-dimensional BIFL data allow the identification and detection of different temporally resolved conformational states. A complementary autocorrelation analysis was performed on the time-dependent fluctuations in fluorescence lifetime and intensity. The consistent results strongly support the hypothesized three-state model of the conformational dynamics of the TMR-DNA duplex with a polar, a nonpolar, and a quenching environment of TMR. | lld:pubmed |
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| pubmed-article:9465054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9465054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9465054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9465054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9465054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9465054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9465054 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9465054 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9465054 | pubmed:author | pubmed-author:BrandLL | lld:pubmed |
| pubmed-article:9465054 | pubmed:author | pubmed-author:GüntherRR | lld:pubmed |
| pubmed-article:9465054 | pubmed:author | pubmed-author:FriehJ MJM | lld:pubmed |
| pubmed-article:9465054 | pubmed:author | pubmed-author:SeidelC ACA | lld:pubmed |
| pubmed-article:9465054 | pubmed:author | pubmed-author:EggelingCC | lld:pubmed |
| pubmed-article:9465054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9465054 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:9465054 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9465054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9465054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9465054 | pubmed:pagination | 1556-61 | lld:pubmed |
| pubmed-article:9465054 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
| pubmed-article:9465054 | pubmed:meshHeading | pubmed-meshheading:9465054-... | lld:pubmed |
| pubmed-article:9465054 | pubmed:meshHeading | pubmed-meshheading:9465054-... | lld:pubmed |
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| pubmed-article:9465054 | pubmed:meshHeading | pubmed-meshheading:9465054-... | lld:pubmed |
| pubmed-article:9465054 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9465054 | pubmed:articleTitle | Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy. | lld:pubmed |
| pubmed-article:9465054 | pubmed:affiliation | Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, D-37077 Göttingen, Germany. | lld:pubmed |
| pubmed-article:9465054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9465054 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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