| pubmed-article:9430689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C0010222 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1414254 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1823197 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1154588 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9430689 | lifeskim:mentions | umls-concept:C0066772 | lld:lifeskim |
| pubmed-article:9430689 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9430689 | pubmed:dateCreated | 1998-2-12 | lld:pubmed |
| pubmed-article:9430689 | pubmed:abstractText | We have functionally expressed the human cDNA encoding the putative lysophosphatidic acid (LPA) receptor Edg-2 (Vzg-1) in Saccharomyces cerevisiae in an attempt to determine the agonist specificity of this G-protein-coupled receptor. LPA activated the pheromone response pathway in S. cerevisiae expressing Edg-2 in a time- and dose-dependent manner as determined by induction of a pheromone-responsive FUS1::lacZ reporter gene. LPA-mediated activation of the pheromone response pathway was dependent on mutational inactivation of the SST2 gene, the GTPase-activating protein for the yeast G alpha protein (the GPA1 gene product). This indicates that, in sst2 delta yeast cells, Edg-2 can efficiently couple to the yeast heterotrimeric G-protein in response to LPA and activate the yeast mitogen-activated protein kinase pathway. The Edg-2 receptor showed a high degree of specificity for LPA; other lyso-glycerophospholipids, sphingosine 1-phosphate, and diacyl-glycerophospholipids did not activate FUS1::lacZ. LPA analogs including a cyclic phosphoester form and ether-linked forms of LPA activated FUS1::lacZ, although fatty acid chains of 6 and 10 carbons did not activate FUS1::lacZ, suggesting a role for the side chain in ligand binding or receptor activation. These results indicate that Edg-2 encodes a highly specific LPA receptor. | lld:pubmed |
| pubmed-article:9430689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9430689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9430689 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9430689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9430689 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9430689 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:TomeiL DLD | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:KawanishiKK | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:GoddardJ GJG | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:WuJ JJJ | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:EricksonJ RJR | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:KieferM CMC | lld:pubmed |
| pubmed-article:9430689 | pubmed:author | pubmed-author:TigyiGG | lld:pubmed |
| pubmed-article:9430689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9430689 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9430689 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9430689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9430689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9430689 | pubmed:pagination | 1506-10 | lld:pubmed |
| pubmed-article:9430689 | pubmed:dateRevised | 2008-10-23 | lld:pubmed |
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| pubmed-article:9430689 | pubmed:meshHeading | pubmed-meshheading:9430689-... | lld:pubmed |
| pubmed-article:9430689 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9430689 | pubmed:articleTitle | Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. | lld:pubmed |
| pubmed-article:9430689 | pubmed:affiliation | LXR Biotechnology Inc., Richmond, California 94804, USA. jerickson@lxr.com | lld:pubmed |
| pubmed-article:9430689 | pubmed:publicationType | Journal Article | lld:pubmed |
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