| pubmed-article:9428739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C1417811 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C1155437 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9428739 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9428739 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9428739 | pubmed:dateCreated | 1998-2-2 | lld:pubmed |
| pubmed-article:9428739 | pubmed:abstractText | Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment. Stabilization of the NPR-C mRNA by PMA indicated that down-regulation of its mRNA was mediated through negative transcriptional regulation. Despite the significant loss of the mRNA, reduction of NPR-C-specific ANP-binding activity after PMA exposure (4 h) was accompanied by a slight decrease in total NPR-C protein (with a 5% loss) and was also produced in the presence of actinomycin D or cycloheximide. The inhibitory effect of a long PMA exposure (18 h) paralleled with a decrease in total NPR-C protein is suggested to be dependent on reduction of de novo NPR-C synthesis. PMA-induced transcriptional and post-translational down-regulation of NPR-C was effectively reversible in the presence of the protein kinase C inhibitor GF109203X. These findings demonstrate that protein kinase C activation down-regulated NPR-C expression through transcriptional and post-translational pathways and that immediate functional receptor loss was mediated via a post-translational mechanism, such as enhanced receptor internalization. | lld:pubmed |
| pubmed-article:9428739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9428739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9428739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9428739 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9428739 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9428739 | pubmed:author | pubmed-author:OmoriKK | lld:pubmed |
| pubmed-article:9428739 | pubmed:author | pubmed-author:AkatsukaHH | lld:pubmed |
| pubmed-article:9428739 | pubmed:author | pubmed-author:YanakaNN | lld:pubmed |
| pubmed-article:9428739 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9428739 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9428739 | pubmed:volume | 418 | lld:pubmed |
| pubmed-article:9428739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9428739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9428739 | pubmed:pagination | 333-6 | lld:pubmed |
| pubmed-article:9428739 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:meshHeading | pubmed-meshheading:9428739-... | lld:pubmed |
| pubmed-article:9428739 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9428739 | pubmed:articleTitle | Protein kinase C activation down-regulates natriuretic peptide receptor C expression via transcriptional and post-translational pathways. | lld:pubmed |
| pubmed-article:9428739 | pubmed:affiliation | Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan. | lld:pubmed |
| pubmed-article:9428739 | pubmed:publicationType | Journal Article | lld:pubmed |
