| pubmed-article:9422506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C1413982 | lld:lifeskim |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C0669174 | lld:lifeskim |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C1413983 | lld:lifeskim |
| pubmed-article:9422506 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:9422506 | pubmed:issue | 6662 | lld:pubmed |
| pubmed-article:9422506 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
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| pubmed-article:9422506 | pubmed:abstractText | The homeostasis of animals is regulated not only by the growth and differentiation of cells, but also by cell death through a process known as apoptosis. Apoptosis is mediated by members of the caspase family of proteases, and eventually causes the degradation of chromosomal DNA. A caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD) have now been identified in the cytoplasmic fraction of mouse lymphoma cells. CAD is a protein of 343 amino acids which carries a nuclear-localization signal; ICAD exists in a long and a short form. Recombinant ICAD specifically inhibits CAD-induced degradation of nuclear DNA and its DNase activity. When CAD is expressed with ICAD in COS cells or in a cell-free system, CAD is produced as a complex with ICAD: treatment with caspase 3 releases the DNase activity which causes DNA fragmentation in nuclei. ICAD therefore seems to function as a chaperone for CAD during its synthesis, remaining complexed with CAD to inhibit its DNase activity; caspases activated by apoptotic stimuli then cleave ICAD, allowing CAD to enter the nucleus and degrade chromosomal DNA. | lld:pubmed |
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| pubmed-article:9422506 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9422506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9422506 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9422506 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:NagataSS | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:YokoyamaHH | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:OkawaKK | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:EnariMM | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:IwamatsuAA | lld:pubmed |
| pubmed-article:9422506 | pubmed:author | pubmed-author:SakahiraHH | lld:pubmed |
| pubmed-article:9422506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9422506 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9422506 | pubmed:volume | 391 | lld:pubmed |
| pubmed-article:9422506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9422506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9422506 | pubmed:pagination | 43-50 | lld:pubmed |
| pubmed-article:9422506 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9422506 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9422506 | pubmed:articleTitle | A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. | lld:pubmed |
| pubmed-article:9422506 | pubmed:affiliation | Department of Genetics, Osaka University Medical School, Suita, Japan. | lld:pubmed |
| pubmed-article:9422506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9422506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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