| pubmed-article:9405581 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0016410 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0178638 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0005508 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C0442711 | lld:lifeskim |
| pubmed-article:9405581 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:9405581 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9405581 | pubmed:dateCreated | 1998-1-22 | lld:pubmed |
| pubmed-article:9405581 | pubmed:abstractText | Stable isotopic protocols for the study of folate absorption were conducted to determine the following: (1) the equivalence of the [13C5] and [2H2] forms of folic acid, and (2) the merits of short-term plasma kinetics from injected and oral doses vs. urinary excretion of [13C5] and [2H2]folates. Another objective was to evaluate the merits of protocols not involving "saturation" of subjects with nonlabeled folate. Oral administration of [13C5] and [2H2]folic acid ( approximately 500 nmol each) to adult subjects (n = 4) yielded an equivalent 24-h urinary excretion of approximately 2% of each dose (molar ratio of urinary [13C5]/[2H2]folates = 0.96 +/- 0.055; mean +/- SEM). Expression of urinary excretion as a ratio of [13C5]/[2H2]folates yielded less within-group variability than seen for absolute excretion of each form of labeled folate. In the second study, subjects received 226 nmol of [2H2]folic acid intravenously and 1010 nmol of [13C5]folic acid orally. Isotopic enrichment of plasma [2H2]folates rose rapidly and returned to near basal values by approximately 2 h postdose. In contrast, enrichment of plasma [13C5]folates was detected until 4 h after dose, whereas enrichment values were far lower than seen with [2H2]folate. Adjusting for the difference in dose, the molar response of plasma area under the curve for isotopic enrichment was 15- to 20-fold greater for injected folates. In view of this very limited short-term plasma response even with a relatively large oral dose, presumably due to hepatic first-pass uptake, these findings suggest that plasma kinetics would be of limited usefulness in assessing the relative bioavailability of nutritionally relevant oral doses of labeled folate. | lld:pubmed |
| pubmed-article:9405581 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9405581 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405581 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9405581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405581 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9405581 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9405581 | pubmed:issn | 0022-3166 | lld:pubmed |
| pubmed-article:9405581 | pubmed:author | pubmed-author:RogersL MLM | lld:pubmed |
| pubmed-article:9405581 | pubmed:author | pubmed-author:BaileyL BLB | lld:pubmed |
| pubmed-article:9405581 | pubmed:author | pubmed-author:GregoryJ FJF | lld:pubmed |
| pubmed-article:9405581 | pubmed:author | pubmed-author:PfeifferC MCM | lld:pubmed |
| pubmed-article:9405581 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9405581 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:9405581 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9405581 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9405581 | pubmed:pagination | 2321-7 | lld:pubmed |
| pubmed-article:9405581 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:meshHeading | pubmed-meshheading:9405581-... | lld:pubmed |
| pubmed-article:9405581 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9405581 | pubmed:articleTitle | A dual-label stable-isotopic protocol is suitable for determination of folate bioavailability in humans: evaluation of urinary excretion and plasma folate kinetics of intravenous and oral doses of [13C5] and [2H2]folic acid. | lld:pubmed |
| pubmed-article:9405581 | pubmed:affiliation | Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA. | lld:pubmed |
| pubmed-article:9405581 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9405581 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9405581 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9405581 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9405581 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9405581 | lld:pubmed |
