| pubmed-article:9381182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:9381182 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:9381182 | pubmed:issue | 5338 | lld:pubmed |
| pubmed-article:9381182 | pubmed:dateCreated | 1997-11-10 | lld:pubmed |
| pubmed-article:9381182 | pubmed:abstractText | Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol. | lld:pubmed |
| pubmed-article:9381182 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9381182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9381182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9381182 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9381182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9381182 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9381182 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:YagiTT | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:NikiHH | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:YasudaMM | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:KawaiNN | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:MiyakawaTT | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:TsuboiKK | lld:pubmed |
| pubmed-article:9381182 | pubmed:author | pubmed-author:KitazawaHH | lld:pubmed |
| pubmed-article:9381182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9381182 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9381182 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:9381182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9381182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9381182 | pubmed:pagination | 698-701 | lld:pubmed |
| pubmed-article:9381182 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9381182 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9381182 | pubmed:articleTitle | Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. | lld:pubmed |
| pubmed-article:9381182 | pubmed:affiliation | Laboratory for Neurobiology of Emotion, Brain Science Institute, RIKEN, Hirosawa, Wako-shi, Saitama-ken 351-01, Japan. | lld:pubmed |
| pubmed-article:9381182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9381182 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9381182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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