| pubmed-article:9366565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0221238 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0243045 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C1707310 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:9366565 | lifeskim:mentions | umls-concept:C0536217 | lld:lifeskim |
| pubmed-article:9366565 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9366565 | pubmed:dateCreated | 1998-1-9 | lld:pubmed |
| pubmed-article:9366565 | pubmed:abstractText | Glomerular injury is characterized by mesangial cell (MC) proliferation and matrix formation. We sought to determine if reducing the activity of cyclin-dependent kinase 2 (CDK2) with the purine analogue, Roscovitine, decreased MC proliferation in vitro and in vivo. Roscovitine (25 microM) inhibited FCS-induced proliferation (P < 0.0001) in cultured MC. Rats with experimental mesangial proliferative glomerulonephritis (Thy1 model) were divided into two groups. A prevention group received daily intraperitoneal injections of Roscovitine in DMSO (2.8 mg/kg) starting at day 1. A treatment group received daily Roscovitine starting at day 3, when MC proliferation was established. Control Thy1 rats received DMSO alone. MC proliferation (PCNA +/OX7 + double immunostaining) was reduced by > 50% at days 5 and 10 in the Roscovitine prevention group, and at day 5 in the treatment group (P < 0.0001). Early administration of Roscovitine reduced immunostaining for collagen type IV, laminin, and fibronectin at days 5 and 10 (r = 0.984; P < 0.001), which was associated with improved renal function (urinary protein/creatinine, blood urea nitrogen, P < 0.05). We conclude that reducing the activity of CDK2 with Roscovitine in experimental glomerulonephritis decreases cell proliferation and matrix production, resulting in improved renal function, and may be a useful therapeutic intervention in disease characterized by proliferation. | lld:pubmed |
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| pubmed-article:9366565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9366565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9366565 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9366565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9366565 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9366565 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9366565 | pubmed:author | pubmed-author:SICC | lld:pubmed |
| pubmed-article:9366565 | pubmed:author | pubmed-author:MeijerLL | lld:pubmed |
| pubmed-article:9366565 | pubmed:author | pubmed-author:ShanklandS... | lld:pubmed |
| pubmed-article:9366565 | pubmed:author | pubmed-author:PippinJ WJW | lld:pubmed |
| pubmed-article:9366565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9366565 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9366565 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:9366565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9366565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9366565 | pubmed:pagination | 2512-20 | lld:pubmed |
| pubmed-article:9366565 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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