| pubmed-article:9350616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9350616 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9350616 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9350616 | lifeskim:mentions | umls-concept:C0227578 | lld:lifeskim |
| pubmed-article:9350616 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:9350616 | lifeskim:mentions | umls-concept:C0600430 | lld:lifeskim |
| pubmed-article:9350616 | pubmed:dateCreated | 1997-12-23 | lld:pubmed |
| pubmed-article:9350616 | pubmed:abstractText | 1. Photodynamic agents, due to their photon-dependent selective activation, can selectively activate a number of physiological processes and may directly modulate signal transduction in a number of cells including pancreatic acinar cells. 2. Activation of the photodynamic agent sulphonated aluminium phthalocyanine (SALPC) triggered recurrent cytosolic calcium ([Ca2+]i) spiking in pancreatic acinar cells. 3. The photodynamically triggered calcium spiking could be blocked by phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor U73122, but not by phosphatidylcholine-specific phospholipase C inhibitor D609. 4. Removal of extracellular Ca2+ abolished spiking, as did 2-aminoethoxydiphenylborate (2-APB), an inhibitory modulator of IP3-mediated Ca2+ release from intracellular stores. 5. These data suggest that SALPC photodynamic action may permanently fix PI-PLC in an active conformation, and this produced recurrent [Ca2+]i spiking. | lld:pubmed |
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| pubmed-article:9350616 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9350616 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9350616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9350616 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9350616 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9350616 | pubmed:author | pubmed-author:KannoTT | lld:pubmed |
| pubmed-article:9350616 | pubmed:author | pubmed-author:CuiZ JZJ | lld:pubmed |
| pubmed-article:9350616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9350616 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9350616 | pubmed:volume | 504 ( Pt 1) | lld:pubmed |
| pubmed-article:9350616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9350616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9350616 | pubmed:pagination | 47-55 | lld:pubmed |
| pubmed-article:9350616 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9350616 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9350616 | pubmed:articleTitle | Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini. | lld:pubmed |
| pubmed-article:9350616 | pubmed:affiliation | Beijing Agricultural University Faculty of Biological Sciences, People's Republic of China. bauic@public.bta.net.cn | lld:pubmed |
| pubmed-article:9350616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9350616 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9350616 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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