| pubmed-article:9334326 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0663446 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:9334326 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:9334326 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:9334326 | pubmed:dateCreated | 1997-11-13 | lld:pubmed |
| pubmed-article:9334326 | pubmed:abstractText | To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo Tat-dependent transcription assays to screen >100,000 compounds. All compounds identified blocked Tat-dependent stimulation of transcriptional elongation. Analysis of a panel of structurally diverse inhibitors indicated that their target is the human homolog of Drosophila positive transcription elongation factor b (P-TEFb). Loss of Tat transactivation in extracts depleted of the kinase subunit of human P-TEFb, PITALRE, was reversed by addition of partially purified human P-TEFb. Transfection experiments with wild-type or kinase knockout PITALRE demonstrated that P-TEFb is required for Tat function. Our results suggest that P-TEFb represents an attractive target for the development of novel HIV therapeutics. | lld:pubmed |
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| pubmed-article:9334326 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9334326 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9334326 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9334326 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9334326 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9334326 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:LeeGG | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:PriceDD | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:FloreyEE | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:TomassiniJJ | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:ZinAA | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:LángJJ | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:LuxSS | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:BlauCC | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:HazudaDD | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:FlygareJJ | lld:pubmed |
| pubmed-article:9334326 | pubmed:author | pubmed-author:ManceboH SHS | lld:pubmed |
| pubmed-article:9334326 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9334326 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9334326 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9334326 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9334326 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9334326 | pubmed:pagination | 2633-44 | lld:pubmed |
| pubmed-article:9334326 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9334326 | pubmed:meshHeading | pubmed-meshheading:9334326-... | lld:pubmed |
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| pubmed-article:9334326 | pubmed:meshHeading | pubmed-meshheading:9334326-... | lld:pubmed |
