| pubmed-article:9312022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0337076 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C0597304 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C1420081 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C1658150 | lld:lifeskim |
| pubmed-article:9312022 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:9312022 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:9312022 | pubmed:dateCreated | 1997-11-14 | lld:pubmed |
| pubmed-article:9312022 | pubmed:abstractText | Grr1 protein of the yeast Saccharomyces cerevisiae is a central component of a glucose signal transduction mechanism responsible for glucose-induced gene expression. It is required for glucose-stimulated regulation of Rgt1, a repressor of several glucose-induced HXT genes. Grr1 also plays a role in regulating the cell cycle, because it is required for degradation of the G1 cyclins Cln1 and Cln2. We discovered that Grr1 physically interacts with Skp1, a protein that has been implicated in a ubiquitin-conjugating enzyme complex that targets for degradation the cell cycle regulators Cln1 and Cln2, and the cyclin-dependent kinase inhibitor Sic1. Thus, Grr1 may regulate the cell cycle and glucose-induced gene expression via ubiquitin-mediated protein degradation. Consistent with this idea, Skp1, like Grr1, was found to be required for glucose-induced HXT gene expression. Two functional domains of Grr1 are required for its interaction with Skp1: 12 leucine-rich repeats (LRR) and an adjacent F-box. The Grr1-Skp1 interaction is enhanced by high levels of glucose. This could provide yeast with a mechanism for coupling nutrient availability to gene expression and cell cycle regulation. | lld:pubmed |
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| pubmed-article:9312022 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9312022 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9312022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9312022 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9312022 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9312022 | pubmed:author | pubmed-author:JohnstonMM | lld:pubmed |
| pubmed-article:9312022 | pubmed:author | pubmed-author:AzaAA | lld:pubmed |
| pubmed-article:9312022 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9312022 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9312022 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9312022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9312022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9312022 | pubmed:pagination | 5629-38 | lld:pubmed |
| pubmed-article:9312022 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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