| pubmed-article:9311789 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C1622968 | lld:lifeskim |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C1160638 | lld:lifeskim |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9311789 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:9311789 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9311789 | pubmed:dateCreated | 1997-10-20 | lld:pubmed |
| pubmed-article:9311789 | pubmed:abstractText | The study of human papillomavirus type 16 (HPV-16) replication has been impaired because of the lack of a cell culture system that stably maintains viral replication. Recently, cervical epithelial cell populations that stably maintain HPV-16 replicons at a copy number of approximately 1,000 per cell were derived from an HPV-16-infected patient (W12 cell clone 20863 [W12-E cells]). We used neutral/neutral and neutral/alkaline two-dimensional gel electrophoretic techniques to characterize HPV-16 DNA replication in these cells. When W12-E cells were maintained in an undifferentiated state mimicking the nonproductive stage of the life cycle, HPV-16 DNA was found to replicate primarily by theta structures in a bidirectional manner. The initiation site of HPV-16 DNA replication was mapped to approximately nucleotide 100, and the termination site was mapped to between nucleotides 3398 and 5990. To study the productive stage of HPV-16 DNA replication, W12-E cells were grown under culture conditions that promote differentiation of epithelial cell types. Under these conditions, where virus-like particles were detected, the mode of viral DNA replication changed from theta structure to what is apparently a rolling circle mode. Additionally, CIN 612-9E cells, which were derived from an HPV-31-infected patient and harbor HPV-31 extrachromosomally, exhibited the same switch in the mode of DNA replication upon induction of differentiation. These data argue that a fundamental switch in the mechanism of viral DNA replication occurs during the life cycle of the papillomavirus. | lld:pubmed |
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| pubmed-article:9311789 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9311789 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311789 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9311789 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9311789 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9311789 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9311789 | pubmed:author | pubmed-author:LambertP FPF | lld:pubmed |
| pubmed-article:9311789 | pubmed:author | pubmed-author:FloresE RER | lld:pubmed |
| pubmed-article:9311789 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9311789 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:9311789 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9311789 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9311789 | pubmed:pagination | 7167-79 | lld:pubmed |
| pubmed-article:9311789 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9311789 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9311789 | pubmed:articleTitle | Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle. | lld:pubmed |
| pubmed-article:9311789 | pubmed:affiliation | McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706, USA. | lld:pubmed |
| pubmed-article:9311789 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9311789 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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