| pubmed-article:9307241 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0026969 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C0750729 | lld:lifeskim |
| pubmed-article:9307241 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:9307241 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9307241 | pubmed:dateCreated | 1997-10-15 | lld:pubmed |
| pubmed-article:9307241 | pubmed:abstractText | This study analyzed the stability of the myelin basic protein (MBP)-specific T-cell receptor (TCR) repertoire during the course of multiple sclerosis (MS) in three patients who were monitored for three years by gadolinium-enhanced magnetic resonance imaging. Bulk-culture T-cell lines (TCLs) were generated from 3-4 time points for each patient, including times of active and quiescent disease. TCR analysis of these TCLs indicated that both the V alpha and V beta usage was similar over time for each patient. Sequencing of TCRs demonstrated conserved complementarity-determining region 3 (CDR3) sequences within TCLs that expressed the same V alpha segment over time, although the J alpha usage was different for each TCR. This indicates that the population of MBP-reactive T-cells is changing during the course of MS, but that host and/or environmental factors may be selecting T-cells with particular MHC/peptide binding domains. | lld:pubmed |
| pubmed-article:9307241 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9307241 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9307241 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9307241 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9307241 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9307241 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9307241 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9307241 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9307241 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:9307241 | pubmed:author | pubmed-author:MartinRR | lld:pubmed |
| pubmed-article:9307241 | pubmed:author | pubmed-author:McFarlandH... | lld:pubmed |
| pubmed-article:9307241 | pubmed:author | pubmed-author:UtzUU | lld:pubmed |
| pubmed-article:9307241 | pubmed:author | pubmed-author:RackeM KMK | lld:pubmed |
| pubmed-article:9307241 | pubmed:author | pubmed-author:Lovett-RackeA... | lld:pubmed |
| pubmed-article:9307241 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9307241 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:9307241 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9307241 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9307241 | pubmed:pagination | 162-71 | lld:pubmed |
| pubmed-article:9307241 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:meshHeading | pubmed-meshheading:9307241-... | lld:pubmed |
| pubmed-article:9307241 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9307241 | pubmed:articleTitle | Longitudinal study of myelin basic protein-specific T-cell receptors during the course of multiple sclerosis. | lld:pubmed |
| pubmed-article:9307241 | pubmed:affiliation | Neuroimmunology Branch, National Institute of Neurologic Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:9307241 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9307241 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9307241 | lld:pubmed |
