| pubmed-article:9306277 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0048897 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9306277 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:9306277 | pubmed:dateCreated | 1997-11-19 | lld:pubmed |
| pubmed-article:9306277 | pubmed:abstractText | 1. Basal electrogenic Cl- secretion, measured as the short-circuit current (Isc), was variable in ileum removed from tetrahydrobiopterin (BH4)-deficient hph-1 mice and wild-type controls in vitro, although values were not significantly different. 2. The basal nitrite release and mucosal cyclic guanosine 3',5'-monophosphate (cyclic GMP) production were similar in control and BH4-deficient ileum. 3. Mucosally added Escherichia coli heat-stable toxin (STa, 55 ng ml-1) increased the nitrite release, cyclic GMP levels and the Isc in control ileum, but its secretory actions were reduced in BH4-deficient ileum. 4. L-Arginine (1 mM) increased the nitrite release, cyclic GMP production and the Isc in control ileum, but the actions were reduced in BH4-deficient ileum. 5. Serosal carbachol (1 mM) stimulated maximum short-circuit currents of similar magnitude in both control and BH4-deficient ileum, whilst nitrite release and cyclic GMP production were minimal. 6. E. coli STa and L-arginine increased electrogenic Cl- secretion across intact mouse ileum in vitro by releasing nitric oxide and elevating mucosal cyclic GMP. The inhibition of these processes in the hph-1 mouse ileum suggests that BH4 may be a target for the modulation of electrogenic transport, and highlight the complexity of the interactions between nitric oxide and cyclic GMP in the gut. | lld:pubmed |
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| pubmed-article:9306277 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9306277 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9306277 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9306277 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9306277 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9306277 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9306277 | pubmed:author | pubmed-author:BrandM PMP | lld:pubmed |
| pubmed-article:9306277 | pubmed:author | pubmed-author:MillaP JPJ | lld:pubmed |
| pubmed-article:9306277 | pubmed:author | pubmed-author:HealesS JSJ | lld:pubmed |
| pubmed-article:9306277 | pubmed:author | pubmed-author:LindleyK JKJ | lld:pubmed |
| pubmed-article:9306277 | pubmed:author | pubmed-author:RolfeV EVE | lld:pubmed |
| pubmed-article:9306277 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9306277 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9306277 | pubmed:volume | 503 ( Pt 2) | lld:pubmed |
| pubmed-article:9306277 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9306277 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9306277 | pubmed:pagination | 347-52 | lld:pubmed |
| pubmed-article:9306277 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9306277 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9306277 | pubmed:articleTitle | Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro. | lld:pubmed |
| pubmed-article:9306277 | pubmed:affiliation | Gastroenterology Unit, Institute of Child Health, University College London, UK. vivienr@wcpn.demon.co.uk | lld:pubmed |
| pubmed-article:9306277 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9306277 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9306277 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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