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pubmed-article:9272389pubmed:abstractTextThe influence of the proton pump inhibitor lansoprazole on strain diversity in Helicobacter pylori infected patients was investigated. Multiple isolates of Helicobacter pylori obtained pre- and post-therapy from gastric antral and body biopsies in 22 patients were compared using the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) for analysis. Post-therapy strains exhibiting novel RAPD-profiles were found in 5 of 22 patients (4 of 11 patients treated with lansoprazole alone and 1 of 11 patients treated with lansoprazole plus amoxicillin). Proton pump inhibition may affect the microecology of the stomach by influencing the colonisation patterns of specific strains.lld:pubmed
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pubmed-article:9272389pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9272389pubmed:articleTitleInfluence of a proton pump inhibitor-based therapy on Helicobacter pylori strain selection.lld:pubmed
pubmed-article:9272389pubmed:affiliationSchool of Microbiology and Immunology, University of New South Wales, Sydney, Australia.lld:pubmed
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pubmed-article:9272389pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed