| pubmed-article:9230303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0243041 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0243044 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C1825534 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9230303 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9230303 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9230303 | pubmed:dateCreated | 1997-8-26 | lld:pubmed |
| pubmed-article:9230303 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:abstractText | Hsp90 molecular chaperones in eukaryotic cells play essential roles in the folding and activation of a range of client proteins involved in cell cycle regulation, steroid hormone responsiveness, and signal transduction. The biochemical mechanism of Hsp90 is poorly understood, and the involvement of ATP in particular is controversial. Crystal structures of complexes between the N-terminal domain of the yeast Hsp90 chaperone and ADP/ATP unambiguously identify a specific adenine nucleotide binding site homologous to the ATP-binding site of DNA gyrase B. This site is the same as that identified for the antitumor agent geldanamycin, suggesting that geldanamycin acts by blocking the binding of nucleotides to Hsp90 and not the binding of incompletely folded client polypeptides as previously suggested. These results finally resolve the question of the direct involvement of ATP in Hsp90 function. | lld:pubmed |
| pubmed-article:9230303 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9230303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9230303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9230303 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9230303 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:O'BrienRR | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:PiperP WPW | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:PearlL HLH | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:ProdromouCC | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:LadburyJ EJE | lld:pubmed |
| pubmed-article:9230303 | pubmed:author | pubmed-author:RoeS MSM | lld:pubmed |
| pubmed-article:9230303 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9230303 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:9230303 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:9230303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9230303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9230303 | pubmed:pagination | 65-75 | lld:pubmed |
| pubmed-article:9230303 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:meshHeading | pubmed-meshheading:9230303-... | lld:pubmed |
| pubmed-article:9230303 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9230303 | pubmed:articleTitle | Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. | lld:pubmed |
| pubmed-article:9230303 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University College London, United Kingdom. | lld:pubmed |
| pubmed-article:9230303 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9230303 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9230303 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| family:PF00204.20 | family:pubmed | pubmed-article:9230303 | lld:pfam |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9230303 | lld:pubmed |
