| pubmed-article:9209314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9209314 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9209314 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9209314 | lifeskim:mentions | umls-concept:C0042749 | lld:lifeskim |
| pubmed-article:9209314 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9209314 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9209314 | pubmed:dateCreated | 1997-8-7 | lld:pubmed |
| pubmed-article:9209314 | pubmed:abstractText | We studied the compatibility of human lymphocyte engraftment and susceptibility to HIV-1 infection in 2 new immunodeficient mice. NOD/Shi-scid mice were generated by backcrossing of the scid mutation into NOD mice while C57BL/6-RAG2(0/0) were generated by knocking out the RAG-2 gene. Human T lymphocytes were reconstituted in new immunodeficient mouse strains. We found that the new immunodeficient mouse strains accepted human PBL engraftment and HIV-1 infection more efficiently than conventional C.B-17-scid mice. Especially in the hu-PBL-NOD/Shi-scid strain, we reproduced the high levels of HIV-1 viremia comparable to or at significantly higher levels than after HIV-1 primary infection. These results indicate that our hu-PBL-NOD-scid animal is useful for investigations of the activation mechanism in HIV-1 replication in vivo and after primary infection. | lld:pubmed |
| pubmed-article:9209314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9209314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9209314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9209314 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9209314 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:ItoMM | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:TanakaYY | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:TanakaTT | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:TanakaRR | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:KawanoYY | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:YamamotoNN | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:MiyasakaMM | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:UeyamaYY | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:KoyanagiYY | lld:pubmed |
| pubmed-article:9209314 | pubmed:author | pubmed-author:MisawaNN | lld:pubmed |
| pubmed-article:9209314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9209314 | pubmed:volume | 11 Suppl 3 | lld:pubmed |
| pubmed-article:9209314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9209314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9209314 | pubmed:pagination | 109-12 | lld:pubmed |
| pubmed-article:9209314 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:9209314 | pubmed:meshHeading | pubmed-meshheading:9209314-... | lld:pubmed |
| pubmed-article:9209314 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9209314 | pubmed:articleTitle | High levels of viremia in hu-PBL-NOD-scid mice with HIV-1 infection. | lld:pubmed |
| pubmed-article:9209314 | pubmed:affiliation | Department of Molecular Virology, Tokyo Medical and Dental University, Japan. | lld:pubmed |
| pubmed-article:9209314 | pubmed:publicationType | Journal Article | lld:pubmed |
