| pubmed-article:9192637 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9192637 | lifeskim:mentions | umls-concept:C0459736 | lld:lifeskim |
| pubmed-article:9192637 | lifeskim:mentions | umls-concept:C1299003 | lld:lifeskim |
| pubmed-article:9192637 | lifeskim:mentions | umls-concept:C0379099 | lld:lifeskim |
| pubmed-article:9192637 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:9192637 | pubmed:dateCreated | 1997-7-21 | lld:pubmed |
| pubmed-article:9192637 | pubmed:abstractText | The mechanisms controlling the production of aqueous humor and the regulation of intraocular pressure are poorly understood. Here, we provide evidence that a vacuolar H+-ATPase (V-ATPase) in the ocular ciliary epithelium is a key component of this process. In intracellular pH (pHi) measurements of isolated ciliary epithelium performed with 2',7-biscarboxyethyl-5(6)-carboxyfluorescein (BCECF), the selective V-ATPase inhibitor bafilomycin A1 slowed the recovery of pHi in response to acute intracellular acidification, demonstrating the presence of V-ATPase in the plasma membrane. In isolated rabbit ciliary body preparations examined under voltage-clamped conditions, bafilomycin A1 produced a concentration-dependent decrease in short-circuit current, and topical application of bafilomycin A1 reduced intraocular pressure in rabbits, indicating an essential role of the V-ATPase in ciliary epithelial ion transport. Immunocytochemistry utilizing antibodies specific for the B1 isoform of the V-ATPase 56-kDa subunit revealed localization of V-ATPase in both the plasma membrane and cytoplasm of the native ciliary epithelium in both rabbit and rat eye. The regional and subcellular distribution of V-ATPase in specific regions of the ciliary process was altered profoundly by isoproterenol and phorbol esters, suggesting that change in the intracellular distribution of the enzyme is a mechanism by which drugs, hormones, and neurotransmitters modify aqueous humor production. | lld:pubmed |
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| pubmed-article:9192637 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9192637 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192637 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9192637 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192637 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9192637 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9192637 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:BrownDD | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:BeckerBB | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:NelsonNN | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:SaitoII | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:KrupinTT | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:GluckS LSL | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:WaxM BMB | lld:pubmed |
| pubmed-article:9192637 | pubmed:author | pubmed-author:TenkovaTT | lld:pubmed |
| pubmed-article:9192637 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9192637 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9192637 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:9192637 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9192637 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9192637 | pubmed:pagination | 6752-7 | lld:pubmed |
| pubmed-article:9192637 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9192637 | pubmed:meshHeading | pubmed-meshheading:9192637-... | lld:pubmed |
| pubmed-article:9192637 | pubmed:meshHeading | pubmed-meshheading:9192637-... | lld:pubmed |
| pubmed-article:9192637 | pubmed:meshHeading | pubmed-meshheading:9192637-... | lld:pubmed |
| pubmed-article:9192637 | pubmed:meshHeading | pubmed-meshheading:9192637-... | lld:pubmed |
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| pubmed-article:9192637 | pubmed:meshHeading | pubmed-meshheading:9192637-... | lld:pubmed |
| pubmed-article:9192637 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9192637 | pubmed:articleTitle | Vacuolar H+-ATPase in ocular ciliary epithelium. | lld:pubmed |
| pubmed-article:9192637 | pubmed:affiliation | Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:9192637 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9192637 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9192637 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:312488 | entrezgene:pubmed | pubmed-article:9192637 | lld:entrezgene |
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