| pubmed-article:9180898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0051755 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C1413246 | lld:lifeskim |
| pubmed-article:9180898 | lifeskim:mentions | umls-concept:C0166825 | lld:lifeskim |
| pubmed-article:9180898 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9180898 | pubmed:dateCreated | 1997-7-1 | lld:pubmed |
| pubmed-article:9180898 | pubmed:abstractText | CD9 is a protein with 4 transmembrane domains, and functions as a cell surface antigen. We have previously reported that CD9 functions as an up-regulator of membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF) activity, which is a potent mitogen as well as a soluble HB-EGF. Anti-CD9 antibodies can neutralize the juxtacrine activity of proHB-EGF when both CD9 and proHB-EGF are coexpressed. We demonstrated here: (1) the CD9 gene was transcribed and translated in the cultured human keratinocytes; (2) anti-CD9 antibody inhibited the approximately 50% growth of human keratinocytes in culture; (3) CD9 was coprecipitated with proHB-EGF and membrane-anchored amphiregulin (proAR), and (4) the transient coexpression of CD9 with proHB-EGF or proAR in mouse L cells up-regulated their juxtacrine growth factor activities. These results suggest that CD9 would make a heterodimer and/or trimer complex with proHB-EGF and proAR, and might cooperate with proHB-EGF and proAR for human keratinocyte growth in a juxtacrine manner. | lld:pubmed |
| pubmed-article:9180898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9180898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9180898 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9180898 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9180898 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:TaniguchiNN | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:YoshikawaKK | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:HashimotoKK | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:InuiSS | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:HigashiyamaSS | lld:pubmed |
| pubmed-article:9180898 | pubmed:author | pubmed-author:HigashiyamaMM | lld:pubmed |
| pubmed-article:9180898 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9180898 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:9180898 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9180898 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9180898 | pubmed:pagination | 291-8 | lld:pubmed |
| pubmed-article:9180898 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:9180898 | pubmed:meshHeading | pubmed-meshheading:9180898-... | lld:pubmed |
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| pubmed-article:9180898 | pubmed:meshHeading | pubmed-meshheading:9180898-... | lld:pubmed |
| pubmed-article:9180898 | pubmed:meshHeading | pubmed-meshheading:9180898-... | lld:pubmed |
| pubmed-article:9180898 | pubmed:meshHeading | pubmed-meshheading:9180898-... | lld:pubmed |
| pubmed-article:9180898 | pubmed:meshHeading | pubmed-meshheading:9180898-... | lld:pubmed |
| pubmed-article:9180898 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9180898 | pubmed:articleTitle | Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. | lld:pubmed |
| pubmed-article:9180898 | pubmed:affiliation | Department of Biochemistry, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:9180898 | pubmed:publicationType | Journal Article | lld:pubmed |
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