| pubmed-article:9165346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9165346 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:9165346 | lifeskim:mentions | umls-concept:C0018497 | lld:lifeskim |
| pubmed-article:9165346 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:9165346 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9165346 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9165346 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9165346 | pubmed:dateCreated | 1997-7-28 | lld:pubmed |
| pubmed-article:9165346 | pubmed:abstractText | Recent immunocytochemical and biochemical studies support a possible neurotransmitter function of dopamine (DA) in the efferent olivocochlear innervation of the guinea pig cochlea. However, the physiological role of DA in cochlear neurotransmission remains unknown. In the present study microiontophoretic techniques were used for testing the action of DA as well as D1- and D2-agonists and -antagonists on spontaneous and N-methyl-D-aspartic acid (NMDA)-, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-, kainic acid- or glutamate-induced firing of afferent fibres in the dendritic region of inner hair cells. Subsynaptic spike activities of anaesthetised guinea pigs were recorded after exposing the third or fourth turn of the cochlea for electrode penetration. Application of DA alone had very little effect on the spontaneous afferent firing rate. In contrast, firing induced by NMDA or AMPA could be depressed by additional administration of DA in a dose-dependent manner. A similar reduction of the induced spike activity was seen after co-administration of D1- or D2-agonists. The action of DA on glutamate agonist-induced firing could be blocked by D1- as well as D2-antagonists. These results show that DA can depress the activated firing rate of the afferent fibres and that this action is mediated by both D1- and D2-receptor subtypes. | lld:pubmed |
| pubmed-article:9165346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9165346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9165346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9165346 | pubmed:month | May | lld:pubmed |
| pubmed-article:9165346 | pubmed:issn | 0378-5955 | lld:pubmed |
| pubmed-article:9165346 | pubmed:author | pubmed-author:FelixDD | lld:pubmed |
| pubmed-article:9165346 | pubmed:author | pubmed-author:ArnoldWW | lld:pubmed |
| pubmed-article:9165346 | pubmed:author | pubmed-author:EhrenbergerKK | lld:pubmed |
| pubmed-article:9165346 | pubmed:author | pubmed-author:OestreicherEE | lld:pubmed |
| pubmed-article:9165346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9165346 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:9165346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9165346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9165346 | pubmed:pagination | 46-52 | lld:pubmed |
| pubmed-article:9165346 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9165346 | pubmed:meshHeading | pubmed-meshheading:9165346-... | lld:pubmed |
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| pubmed-article:9165346 | pubmed:meshHeading | pubmed-meshheading:9165346-... | lld:pubmed |
| pubmed-article:9165346 | pubmed:meshHeading | pubmed-meshheading:9165346-... | lld:pubmed |
| pubmed-article:9165346 | pubmed:meshHeading | pubmed-meshheading:9165346-... | lld:pubmed |
| pubmed-article:9165346 | pubmed:meshHeading | pubmed-meshheading:9165346-... | lld:pubmed |
| pubmed-article:9165346 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9165346 | pubmed:articleTitle | Dopamine regulates the glutamatergic inner hair cell activity in guinea pigs. | lld:pubmed |
| pubmed-article:9165346 | pubmed:affiliation | Division of Neurobiology, University of Berne, Switzerland. | lld:pubmed |
| pubmed-article:9165346 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9165346 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9165346 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9165346 | lld:pubmed |
