Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9162192rdf:typepubmed:Citationlld:pubmed
pubmed-article:9162192lifeskim:mentionsumls-concept:C1518932lld:lifeskim
pubmed-article:9162192lifeskim:mentionsumls-concept:C1333016lld:lifeskim
pubmed-article:9162192lifeskim:mentionsumls-concept:C1520972lld:lifeskim
pubmed-article:9162192lifeskim:mentionsumls-concept:C1442161lld:lifeskim
pubmed-article:9162192lifeskim:mentionsumls-concept:C0162789lld:lifeskim
pubmed-article:9162192lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:9162192pubmed:issue1lld:pubmed
pubmed-article:9162192pubmed:dateCreated1997-5-27lld:pubmed
pubmed-article:9162192pubmed:abstractTextChildhood endodermal sinus tumors (CESTs) are a unique category of germ cell tumors involving the testis and extragonadal region in children less than 4 years of age. Recent studies of CEST have shown recurrent cytogenetic abnormalities involving the short arm of chromosome 1, most commonly, a deletion of distal 1p. Experience with neuroblastomas has shown that cytogenetic analyses may underestimate the frequency of 1p deletion. To determine the frequency of deletion of Ip in CEST and to verify that 1p is, in fact, deleted and not translocated, we analyzed ten tumors by two-color fluorescence in situ hybridization on single-cell suspensions of interphase nuclei by using a cosmid probe from the PITSLRE kinase (p58) locus (previously mapped to 1p36) cohybridized with plasmid probe pUC1.77 (which recognizes the 1q heterochromatic region) to determine the copy number of chromosome 1. Eight of the ten tumors examined showed evidence of deletion of 1p36. Five of the eight tumors exhibited multiple subdones, and all subdones showed deletion of at least one copy of 1p36, indicating that the deletion probably occurred before the development of chromosome 1 aneusomy. We conclude that deletions of the short arm of chromosome 1, specifically 1p36, do occur in CEST and probably occur at a, higher incidence than that found in neuroblastoma Further studies are needed to determine the degree of overlap of the common area of deletion in CEST with that of neuroblastoma and to determine whether 1p deletion in CEST has prognostic significance.lld:pubmed
pubmed-article:9162192pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9162192pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9162192pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9162192pubmed:languageenglld:pubmed
pubmed-article:9162192pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9162192pubmed:citationSubsetIMlld:pubmed
pubmed-article:9162192pubmed:statusMEDLINElld:pubmed
pubmed-article:9162192pubmed:monthMaylld:pubmed
pubmed-article:9162192pubmed:issn1045-2257lld:pubmed
pubmed-article:9162192pubmed:authorpubmed-author:GriffinC ACAlld:pubmed
pubmed-article:9162192pubmed:authorpubmed-author:LookA TATlld:pubmed
pubmed-article:9162192pubmed:authorpubmed-author:ValentineM...lld:pubmed
pubmed-article:9162192pubmed:authorpubmed-author:PerlmanE JEJlld:pubmed
pubmed-article:9162192pubmed:issnTypePrintlld:pubmed
pubmed-article:9162192pubmed:volume16lld:pubmed
pubmed-article:9162192pubmed:ownerNLMlld:pubmed
pubmed-article:9162192pubmed:authorsCompleteYlld:pubmed
pubmed-article:9162192pubmed:pagination15-20lld:pubmed
pubmed-article:9162192pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:meshHeadingpubmed-meshheading:9162192-...lld:pubmed
pubmed-article:9162192pubmed:year1996lld:pubmed
pubmed-article:9162192pubmed:articleTitleDeletion of 1p36 in childhood endodermal sinus tumors by two-color fluorescence in situ hybridization: a pediatric oncology group study.lld:pubmed
pubmed-article:9162192pubmed:affiliationDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.lld:pubmed
pubmed-article:9162192pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9162192pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9162192pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9162192lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9162192lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9162192lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9162192lld:pubmed