| pubmed-article:9139956 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0003847 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0224377 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C1136143 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:9139956 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:9139956 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:9139956 | pubmed:dateCreated | 1997-5-28 | lld:pubmed |
| pubmed-article:9139956 | pubmed:abstractText | Leukocyte rolling and adhesion are generally observed in venules but rarely observed in arterioles. With the use of intravital microscopy, we found that a 4-h treatment with interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) dose dependently induced leukocyte rolling and adhesion in arterioles of the mouse cremaster muscle. The rolling response lasted more than 24 h and was completely inhibited by treatment with the sulfated polysaccharide fucoidin. Moreover, we found that costimulation with IL-1beta and TNF-alpha for 4 h synergistically increased arteriolar leukocyte rolling, i.e., threshold doses of IL-1beta and TNF-alpha together caused a more than 10-fold increase of rolling in arterioles compared with the sum of the individual responses. This rolling interaction was abolished by treatment with a monoclonal antibody directed against P-selectin (RB40.34), but it apparently was unaffected by a monoclonal antibody against L-selectin (MEL-14). Taken together, our functional data show that IL-1beta and TNF-alpha separately induce and synergistically increase P-selectin-dependent leukocyte rolling and firm adhesion in mouse cremaster arterioles. | lld:pubmed |
| pubmed-article:9139956 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9139956 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9139956 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9139956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9139956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9139956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9139956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9139956 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9139956 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9139956 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9139956 | pubmed:author | pubmed-author:RathWW | lld:pubmed |
| pubmed-article:9139956 | pubmed:author | pubmed-author:LindbomLL | lld:pubmed |
| pubmed-article:9139956 | pubmed:author | pubmed-author:ThorlaciusHH | lld:pubmed |
| pubmed-article:9139956 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9139956 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9139956 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9139956 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9139956 | pubmed:pagination | H1725-9 | lld:pubmed |
| pubmed-article:9139956 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9139956 | pubmed:meshHeading | pubmed-meshheading:9139956-... | lld:pubmed |
| pubmed-article:9139956 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9139956 | pubmed:articleTitle | Cytokine-induced leukocyte rolling in mouse cremaster muscle arterioles in P-selectin dependent. | lld:pubmed |
| pubmed-article:9139956 | pubmed:affiliation | Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:9139956 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9139956 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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