Linked Life Data

9092950

Source:http://linkedlifedata.com/resource/pubmed/id/9092950

Statements in which the resource exists.
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pubmed-article:9092950pubmed:abstractTextWe investigated the effect of glucose deprivation treatment on clonogenicity in multidrug-resistant human breast carcinoma MCF-7/ADR cells. Survival of MCF-7/ADR cells decreased exponentially up to 8 hours of incubation in the glucose-free medium. The surviving fraction of these cells for 8 hours of glucose-deprivation treatment was 1.5 x 10(-3). Photomicrographs and gel electrophoresis data suggest that glucose deprivation-induced cell death is associated with apoptosis. Data from western and northern blots showed an induction of c-myc gene expression during treatment with glucose-free medium in MCF-7/ADR cells. MCF-7/ADR cells transfected with c-myc antisense oligodeoxynucleotides became resistant to glucose deprivation-induced apoptosis. Overexpression of bcl-2 gene protected MCF-7/ADR cells from this apoptotic cell death. Taken together, these results indicate that c-myc expression is a necessary component of glucose-free medium induced apoptosis and bcl-2 prevents apoptotic death induced by c-myc.lld:pubmed
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pubmed-article:9092950pubmed:volume110 ( Pt 5)lld:pubmed
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pubmed-article:9092950pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9092950pubmed:articleTitleGlucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death.lld:pubmed
pubmed-article:9092950pubmed:affiliationDepartment of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.lld:pubmed
pubmed-article:9092950pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9092950pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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