| pubmed-article:9070745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0596630 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0015283 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:9070745 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9070745 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9070745 | pubmed:dateCreated | 1997-6-10 | lld:pubmed |
| pubmed-article:9070745 | pubmed:abstractText | Using single-cell imaging, we investigated developmental changes in the modulation of KCl-evoked Ca2+ entry by various voltage-dependent Ca2+ channels and the coupling of these channels to exocytosis in cultured cerebellar granule neurons. A component of the KCl-evoked Ca2+ elevation sensitive to nifedipine and localized at cell somata, decreases with culture age. A component blocked by 200 nM omega-Agatoxin-IVA increases with age and whilst localized primarily at the cell somata, also becomes evident at the neurites. The change in activity between nifedipine-sensitive Ca2+ channels and omega-Agatoxin-IVA-sensitive Ca2+ channels occurs at 13 days in vitro at cell somata. A component of Ca2+ entry insensitive to nifedipine and 200 nM omega-Agatoxin-IVA is localized primarily at the neurites and is apparent at all ages. Single-cell imaging of exocytosis using FM1-43 destaining indicates that the residual, but not the nifedipine- or omega-Agatoxin-IVA-sensitive components of Ca2+ entry, modulates exocytosis. However cells cultured for 20-26 days develop a component of Ca2+ entry at the neurites which is sensitive to 200 nM omega-Agatoxin-IVA and omega-Conotoxin-MVIIC and which partially controls release. Immunolocalization studies reveal that binding sites for omega-Conotoxin-GVIA are present throughout development, even though this toxin does not inhibit KCl-evoked [Ca2+]c elevations or exocytosis. 300 nM omega-Agatoxin-IVA labels both somata and, at later developmental stages, neurites, consistent with the functional studies. | lld:pubmed |
| pubmed-article:9070745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9070745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9070745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9070745 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9070745 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:RitchieJJ | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:PocockJJ | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:SmithWW | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:NichollsDD | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:BowmanDD | lld:pubmed |
| pubmed-article:9070745 | pubmed:author | pubmed-author:HarroldJJ | lld:pubmed |
| pubmed-article:9070745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9070745 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:9070745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9070745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9070745 | pubmed:pagination | 683-94 | lld:pubmed |
| pubmed-article:9070745 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:9070745 | pubmed:meshHeading | pubmed-meshheading:9070745-... | lld:pubmed |
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| pubmed-article:9070745 | pubmed:meshHeading | pubmed-meshheading:9070745-... | lld:pubmed |
| pubmed-article:9070745 | pubmed:meshHeading | pubmed-meshheading:9070745-... | lld:pubmed |
| pubmed-article:9070745 | pubmed:meshHeading | pubmed-meshheading:9070745-... | lld:pubmed |
| pubmed-article:9070745 | pubmed:meshHeading | pubmed-meshheading:9070745-... | lld:pubmed |
| pubmed-article:9070745 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9070745 | pubmed:articleTitle | The development of Ca2+ channel responses and their coupling to exocytosis in cultured cerebellar granule cells. | lld:pubmed |
| pubmed-article:9070745 | pubmed:affiliation | Neurosciences Institute, Department of Pharmacology, University of Dundee, U.K. | lld:pubmed |
| pubmed-article:9070745 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9070745 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
