| pubmed-article:9045870 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C0000530 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C0268124 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C1417861 | lld:lifeskim |
| pubmed-article:9045870 | lifeskim:mentions | umls-concept:C1621315 | lld:lifeskim |
| pubmed-article:9045870 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9045870 | pubmed:dateCreated | 1997-3-20 | lld:pubmed |
| pubmed-article:9045870 | pubmed:abstractText | The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not normally expressed during thymocyte development until the medullary stage. To determine whether earlier expression would lead to adenosine accumulation and/or be deleterious for thymocyte maturation, thymic purine metabolism, and T cell differentiation were studied in lckNT transgenic mice overexpressing 5'-NT in cortical thymocytes under the control of the lck proximal promoter. In spite of a 100-fold elevation in thymic 5'-NT activity, transgenic adenosine levels were unchanged and T cell immunity was normal. Inosine, the product of adenosine deamination, was elevated more than twofold, however, indicating that adenosine deaminase (ADA) can prevent the accumulation of adenosine, even with a dramatic increase in 5'-NT activity, and demonstrating the availability of 5'-NT substrates in the thymus for the first time. Thymic adenosine concentrations of mice treated with the ADA inhibitor 2'-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5'-NT, is mainly responsible for low thymic adenosine levels. The adenosine concentrations in dCF-treated mice are sufficient to cause adenosine receptor-mediated thymocyte apoptosis in vitro, suggesting that adenosine accumulation could play a role in ADA-deficient severe combined immunodeficiency. | lld:pubmed |
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| pubmed-article:9045870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9045870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9045870 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9045870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9045870 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9045870 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:ThompsonL FLF | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:FranklinMM | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:KnudsenT BTB | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:Jamshedur... | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:RestaRR | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:NadonN LNL | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:LaurentA BAB | lld:pubmed |
| pubmed-article:9045870 | pubmed:author | pubmed-author:HookerS WSW | lld:pubmed |
| pubmed-article:9045870 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9045870 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9045870 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:9045870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9045870 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9045870 | pubmed:pagination | 676-83 | lld:pubmed |
| pubmed-article:9045870 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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