| pubmed-article:9029495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9029495 | lifeskim:mentions | umls-concept:C0295352 | lld:lifeskim |
| pubmed-article:9029495 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:9029495 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:9029495 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9029495 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:9029495 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:9029495 | pubmed:dateCreated | 1997-5-6 | lld:pubmed |
| pubmed-article:9029495 | pubmed:abstractText | 5-HT3 receptor-mediated ion currents evoked by the full agonists 5-hydroxy-tryptamine (5-HT), quaternary 5-HT (5-HTQ), meta-chlorophenylbiguanide (mCPBG) and the partial agonists dopamine and tryptamine have been investigated in whole-cell voltage clamp experiments on N1E-115 mouse neuroblastoma cells. All agonists desensitize the 5-HT3 receptor completely with a steep concentration dependence and a potency order of: mCPBG > 5-HTQ approximately 5-HT > > tryptamine > dopamine. The time course of recovery from desensitization depends on the agonist used. Recovery from partial agonist-induced desensitization is single exponential, whereas the desensitization induced by full agonists recovers with sigmoid kinetics, suggesting at least 3 transitions between 4 states. It is concluded that full and partial agonists induce distinct desensitized states. | lld:pubmed |
| pubmed-article:9029495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9029495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9029495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9029495 | pubmed:issn | 1079-9893 | lld:pubmed |
| pubmed-article:9029495 | pubmed:author | pubmed-author:VijverbergH... | lld:pubmed |
| pubmed-article:9029495 | pubmed:author | pubmed-author:van HooftJ... | lld:pubmed |
| pubmed-article:9029495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9029495 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9029495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9029495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9029495 | pubmed:pagination | 267-77 | lld:pubmed |
| pubmed-article:9029495 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:meshHeading | pubmed-meshheading:9029495-... | lld:pubmed |
| pubmed-article:9029495 | pubmed:articleTitle | Full and partial agonists induce distinct desensitized states of the 5-HT3 receptor. | lld:pubmed |
| pubmed-article:9029495 | pubmed:affiliation | Research Institute of Toxicology, Utrecht University, The Netherlands. | lld:pubmed |
| pubmed-article:9029495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9029495 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
