| pubmed-article:8993478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C0014507 | lld:lifeskim |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8993478 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:8993478 | pubmed:dateCreated | 1997-2-4 | lld:pubmed |
| pubmed-article:8993478 | pubmed:abstractText | Our studies of the APOE genotype in AD confirm a strong association of the epsilon 4 allele with development of AD and a decreased risk associated with epsilon 2. From a clinical/neuropathological perspective, the major effects of APOE epsilon 4 are to lower the age of onset and to increase the amount of A beta deposit in the brain. Neither rate of progression nor number of neurofibrillary tangles were affected. We also carried out a longitudinal population-based assessment of the APOE genotype to determine the risk for developing cognitive impairment of someone in the general population based on APOE genotype. APOE epsilon 4 carried about 1.4-fold increased risk, and APOE epsilon 2 about 1.7-fold decreased risk. Thus, inheritance of APOE epsilon 4 is a major biological risk factor for AD, but it has limited utility as a prognostic indicator for development of dementia in an individual. | lld:pubmed |
| pubmed-article:8993478 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8993478 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8993478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8993478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8993478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8993478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8993478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8993478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8993478 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8993478 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:GrowdonJ HJH | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:WallaceRR | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:ChungHH | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:GreenbergSS | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:BriggsMM | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:NicholsSS | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:HymanB TBT | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:WestH LHL | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:RebeckG WGW | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:MuiSS | lld:pubmed |
| pubmed-article:8993478 | pubmed:author | pubmed-author:Gomez-IslaTT | lld:pubmed |
| pubmed-article:8993478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8993478 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8993478 | pubmed:volume | 802 | lld:pubmed |
| pubmed-article:8993478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8993478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8993478 | pubmed:pagination | 1-5 | lld:pubmed |
| pubmed-article:8993478 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8993478 | pubmed:meshHeading | pubmed-meshheading:8993478-... | lld:pubmed |
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| pubmed-article:8993478 | pubmed:meshHeading | pubmed-meshheading:8993478-... | lld:pubmed |
| pubmed-article:8993478 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8993478 | pubmed:articleTitle | Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. | lld:pubmed |
| pubmed-article:8993478 | pubmed:affiliation | Neurology Service, Massachusetts General Hospital, Boston 02114, USA. | lld:pubmed |
| pubmed-article:8993478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8993478 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8993478 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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