| pubmed-article:8978464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8978464 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8978464 | lifeskim:mentions | umls-concept:C0031670 | lld:lifeskim |
| pubmed-article:8978464 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:8978464 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8978464 | pubmed:dateCreated | 1997-3-17 | lld:pubmed |
| pubmed-article:8978464 | pubmed:abstractText | We examined the effect of basic fibroblast growth factor (bFGF) on the activation of phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells. bFGF stimulated both the formations of choline (EC50 was 30 ng/ml) and inositol phosphates (EC50 was 10 ng/ml). Calphostin C, an inhibitor of protein kinase C (PKC), had little effect on the bFGF-induced formation of choline. bFGF stimulated the formation of choline also in PKC down regulated cells. Genistein and methyl 2,5-dihydroxycinnamate, inhibitors of protein tyrosine kinases, significantly suppressed the bFGF-induced formation of choline. Sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, enhanced the bFGF-induced formation of choline. In vitro kinase assay for FGF receptors revealed that FGF receptor 1 and 2 were autophosphorylated after FGF stimulation. bFGF dose-dependently stimulated DNA synthesis of these cells. These results strongly suggest that bFGF activates phosphatidylcholine-hydrolyzing phospholipase D through the activation of tyrosine kinase, but independently of PKC activated by phosphoinositide hydrolysis in osteoblast-like cells. | lld:pubmed |
| pubmed-article:8978464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8978464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8978464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8978464 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8978464 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:8978464 | pubmed:author | pubmed-author:SuzukiAA | lld:pubmed |
| pubmed-article:8978464 | pubmed:author | pubmed-author:KandaSS | lld:pubmed |
| pubmed-article:8978464 | pubmed:author | pubmed-author:ShinodaJJ | lld:pubmed |
| pubmed-article:8978464 | pubmed:author | pubmed-author:OisoYY | lld:pubmed |
| pubmed-article:8978464 | pubmed:author | pubmed-author:KozawaOO | lld:pubmed |
| pubmed-article:8978464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8978464 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8978464 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:8978464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8978464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8978464 | pubmed:pagination | 491-9 | lld:pubmed |
| pubmed-article:8978464 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8978464 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8978464 | pubmed:articleTitle | Basic fibroblast growth factor stimulates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells. | lld:pubmed |
| pubmed-article:8978464 | pubmed:affiliation | First Department of Internal Medicine, Nagoya University, School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8978464 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8978464 | lld:pubmed |
