| pubmed-article:8975884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8975884 | lifeskim:mentions | umls-concept:C0128897 | lld:lifeskim |
| pubmed-article:8975884 | lifeskim:mentions | umls-concept:C0600431 | lld:lifeskim |
| pubmed-article:8975884 | lifeskim:mentions | umls-concept:C1372999 | lld:lifeskim |
| pubmed-article:8975884 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8975884 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8975884 | pubmed:dateCreated | 1997-1-22 | lld:pubmed |
| pubmed-article:8975884 | pubmed:abstractText | Monocyte chemoattractant protein-1 (MCP-1) is a member of the Cys-Cys chemokine family. Two related MCP-1 receptors have been identified (CC-CKR2A and CC-CKR2B), although the precise kinetics of ligand binding and calcium signaling of these receptors has yet to be investigated. To examine this more closely, the human MCP-1 receptors were cloned and expressed in Chinese hamster ovary (CHO) cells. Membranes prepared from cells expressing CC-CKR2B bind MCP-1 selectively and with high affinity (Kd = 120 pM). MCP-1 stimulation of recombinant CHO cells expressing CC-CKR2B induces a rapid increase in intracellular Ca2+ through both receptor-operated Ca2+ channels and mobilization of Ca2+ from intracellular stores, and leads to a rapid temperature-dependent internalization of the ligand/receptor complexes. In contrast, recombinant CHO cells expressing CC-CKR2A, and membranes prepared from these cells, fail to bind detectable levels of MCP-1. However, MCP-1 stimulation of cells expressing CC-CKR2A induces a small but significant increase in intracellular Ca2+. Repeated stimulation of these cells with MCP-1 leads to a potentiation of the response to a level comparable to that seen in cells expressing CC-CKR2B. These observations suggest that the levels of cell surface CC-CKR2A are controlled by novel mechanisms. | lld:pubmed |
| pubmed-article:8975884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8975884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8975884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8975884 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8975884 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:GreerMM | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:WilsonRR | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:AndersonMM | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:MartinLL | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:ReillyCC | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:HollisMM | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:BarrattDD | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:NeedhamMM | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:CerilloGG | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:WarburtonHH | lld:pubmed |
| pubmed-article:8975884 | pubmed:author | pubmed-author:SturgessNN | lld:pubmed |
| pubmed-article:8975884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8975884 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:8975884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8975884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8975884 | pubmed:pagination | 793-803 | lld:pubmed |
| pubmed-article:8975884 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
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| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
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| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
| pubmed-article:8975884 | pubmed:meshHeading | pubmed-meshheading:8975884-... | lld:pubmed |
| pubmed-article:8975884 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8975884 | pubmed:articleTitle | Monocyte chemoattractant protein-1: receptor interactions and calcium signaling mechanisms. | lld:pubmed |
| pubmed-article:8975884 | pubmed:affiliation | Cardiovascular & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Cheshire, United Kingdom. | lld:pubmed |
| pubmed-article:8975884 | pubmed:publicationType | Journal Article | lld:pubmed |
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