| pubmed-article:8974188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8974188 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:8974188 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:8974188 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8974188 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8974188 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8974188 | pubmed:dateCreated | 1997-4-1 | lld:pubmed |
| pubmed-article:8974188 | pubmed:abstractText | Fourteen healthy male subjects were studied under resting conditions for 24 or 48 h. The 24-h variations of ACTH and cortisol with peaks in the morning were confirmed. Interleukin-2 release was profoundly reduced at 8: 00. A cosine function could be fitted to lymphocyte subpopulations including populations such as T helper-memory cells (CD4+/CDw29) and HLA-DR-bearing cells displaying peak values during the night and minimal values at 9:00. Numbers of natural killer cells (CD57) were not correlated to other cell populations and no rhythm could be detected. Interleukin- 1 beta was detectable in some plasma samples only with an interleukin- 1 ELISA kit (Quantakine HS(R)), but neither a 24-h rhythm nor reproducible results could be obtained for day 1 and 2 of the study. We conclude that there might be a temporal relation between the parameters analyzed: Higher levels of endogenous cortisol in the morning hours probably inhibit the cellular interleukin-2 synthesis and are responsible for an enhanced migration of lymphocytes from the blood into the tissues of the reticuloendothelial system. These results might be indicative of a circadian organization of the immune system which may play a role in both physiological and pathological functioning. | lld:pubmed |
| pubmed-article:8974188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8974188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8974188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8974188 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8974188 | pubmed:issn | 0742-0528 | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:MaierHH | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:KirchWW | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:PalaGG | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:ZabelPP | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:HinrichsenHH | lld:pubmed |
| pubmed-article:8974188 | pubmed:author | pubmed-author:PostlerEE | lld:pubmed |
| pubmed-article:8974188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8974188 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8974188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8974188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8974188 | pubmed:pagination | 423-34 | lld:pubmed |
| pubmed-article:8974188 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:meshHeading | pubmed-meshheading:8974188-... | lld:pubmed |
| pubmed-article:8974188 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8974188 | pubmed:articleTitle | Twenty-four-hour analysis of lymphocyte subpopulations and cytokines in healthy subjects. | lld:pubmed |
| pubmed-article:8974188 | pubmed:affiliation | Clinic of Anaesthesiology und Operative Intensive Care, Christian-Albrechts-University, Kiel, Germany. | lld:pubmed |
| pubmed-article:8974188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8974188 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8974188 | lld:pubmed |
