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pubmed-article:8973358pubmed:abstractTextThe galactose operon encoding a repressor and genes for the Leloir pathway for galactose metabolism (galactokinase, galactose-1-phosphate-uridyl transferase and UDP glucose-4-epimerase) was located adjacent to the multiple sugar metabolism (msm) operon on the chromosome of Streptococcus mutans Ingbritt (serotype c) and the complete nucleotide sequence of this 5-kilobase region was determined. The Leloir pathway was induced by the presence of galactose in the growth medium or following the release of intracellular galactose after uptake and cleavage of alpha-galactosides by the multiple sugar metabolism system. Analysis of the mechanism of galactose transport confirmed the absence of a galactose-specific phosphotransferase system and suggested the presence of an inducible galactose permease. Evidence is presented that galactose transport is independent of the proton motive force and may be ATP-dependent.lld:pubmed
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pubmed-article:8973358pubmed:articleTitleOrganization and nucleotide sequence of the Streptococcus mutans galactose operon.lld:pubmed
pubmed-article:8973358pubmed:affiliationDepartment of Microbiology and Immunology, University of Oklahoma, Oklahoma City 73104, USA.lld:pubmed
pubmed-article:8973358pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8973358pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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