| pubmed-article:8943401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C0002092 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C0032385 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C0330312 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C1824952 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C1149309 | lld:lifeskim |
| pubmed-article:8943401 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8943401 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8943401 | pubmed:dateCreated | 1996-12-27 | lld:pubmed |
| pubmed-article:8943401 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943401 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943401 | pubmed:abstractText | Bet v 1 and homologous proteins represent major cross-reactive allergens for more than 95% of tree pollen-, fruit-, and vegetable-allergic individuals. To study the interaction of Bet v 1 and the immune system, we characterized a Bet v 1-specific mAb, Bip 1. Soluble rBip 1 Fabs were expressed in Escherichia coli and purified by affinity chromatography using immobilized Bet v 1. Bip 1 Fabs displayed a cross-reactivity to homologous allergens comparable with that of IgE Abs from allergic patients. Preincubation of Bet v 1 with Bip 1 led to an up to fivefold increase of allergic patients' IgE binding to Bet v 1. This enhancement in IgE binding may be interpreted as stabilization of a Bet v 1 state, in which certain IgE epitopes are better applicable. It also shows that allergic patients possess IgE Abs directed against different Bet v 1 conformations. The modulation of Ab binding to a given Ag by other Abs was observed also for human Bet v 1-specific IgG Abs, and may represent a novel mechanism for the regulation of specific humoral immune responses in a complex network. | lld:pubmed |
| pubmed-article:8943401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8943401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943401 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8943401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8943401 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8943401 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:KraftDD | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:PastoreAA | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:ValentaRR | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:LafferSS | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:SteinbergerPP | lld:pubmed |
| pubmed-article:8943401 | pubmed:author | pubmed-author:VangelistaLL | lld:pubmed |
| pubmed-article:8943401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8943401 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8943401 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8943401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8943401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8943401 | pubmed:pagination | 4953-62 | lld:pubmed |
| pubmed-article:8943401 | pubmed:dateRevised | 2011-6-21 | lld:pubmed |
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| pubmed-article:8943401 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8943401 | pubmed:articleTitle | Molecular characterization of Bip 1, a monoclonal antibody that modulates IgE binding to birch pollen allergen, Bet v 1. | lld:pubmed |
| pubmed-article:8943401 | pubmed:affiliation | Institute of General and Experimental Pathology, Vienna General Hospital (AKH), University of Vienna, Austria. | lld:pubmed |
| pubmed-article:8943401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8943401 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8943401 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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