| pubmed-article:8939724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8939724 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8939724 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:8939724 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:8939724 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8939724 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8939724 | pubmed:dateCreated | 1997-5-13 | lld:pubmed |
| pubmed-article:8939724 | pubmed:abstractText | cAMP functions as the key extracellular signaling molecule controlling Dictyostelium development acting through classic G-protein-coupled/serpentine receptors. Whereas aggregation is controlled by nanomolar pulses of cAMP, a more continuous micromolar signal controls multicellular differentiation by activating a transcriptional cascade via a receptor-mediated but non G-protein-coupled pathway. Potential mechanisms by which extracellular cAMP functions to differentially control aggregation followed by morphogenesis and cell-type differentiation are discussed. This review also summarizes new findings elucidating pathways controlling cell-type regulation in this organism, including signaling cascades mediated by glycogen synthase kinase 3 and cAMP-dependent protein kinase, key regulators of cell-type differentiation in metazoans, and newly identified transcription factors. | lld:pubmed |
| pubmed-article:8939724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8939724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8939724 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8939724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8939724 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8939724 | pubmed:issn | 0959-437X | lld:pubmed |
| pubmed-article:8939724 | pubmed:author | pubmed-author:FirtelR ARA | lld:pubmed |
| pubmed-article:8939724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8939724 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:8939724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8939724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8939724 | pubmed:pagination | 545-54 | lld:pubmed |
| pubmed-article:8939724 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8939724 | pubmed:meshHeading | pubmed-meshheading:8939724-... | lld:pubmed |
| pubmed-article:8939724 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8939724 | pubmed:articleTitle | Interacting signaling pathways controlling multicellular development in Dictyostelium. | lld:pubmed |
| pubmed-article:8939724 | pubmed:affiliation | Department of Biology, Center for Molecular Genetics, University of California at San Diego, La Jolla 92093-0634, USA. rafirtel@ucsd.edu | lld:pubmed |
| pubmed-article:8939724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8939724 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8939724 | pubmed:publicationType | Review | lld:pubmed |
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