| pubmed-article:8938450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C2245017 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C1520840 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C1417650 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C1516050 | lld:lifeskim |
| pubmed-article:8938450 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:8938450 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8938450 | pubmed:dateCreated | 1997-3-27 | lld:pubmed |
| pubmed-article:8938450 | pubmed:abstractText | The cDNA for the PSST subunit of human mitochondrial nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase [complex I; NADH dehydrogenase (ubiquinone), Fe-S (20 kDa); EC 1.6.5.3] was generated by polymerase chain reaction (PCR) amplification of human cDNA. The sequence of the mature protein deduced from the cDNA codes for a protein that is closely related to the bovine protein (93% homology). Nine conservative substitutions are found in the mature protein, mainly in the N and C terminal regions. The mature human protein is missing four amino acids (PAAL) close to the N terminus that are present in the bovine protein. The N terminus of the mature protein is preceded by a presequence of 38 amino acids that, although quite different from its bovine counterpart (52% homology), has properties that are characteristic of a mitochondrial import sequence. Southern hybridization analysis predicts an estimated gene size of 3.8 kb. Northern hybridization analysis of mRNA from fibroblasts of complex I-deficient patients revealed no size or transcript level abnormalities. The cDNA of the PSST protein was used to investigate tissue-specific expression and to localize the gene for this subunit to chromosome 19p13. | lld:pubmed |
| pubmed-article:8938450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8938450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8938450 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8938450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8938450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8938450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8938450 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8938450 | pubmed:issn | 0888-7543 | lld:pubmed |
| pubmed-article:8938450 | pubmed:author | pubmed-author:RobinsonB HBH | lld:pubmed |
| pubmed-article:8938450 | pubmed:author | pubmed-author:DuncanA MAM | lld:pubmed |
| pubmed-article:8938450 | pubmed:author | pubmed-author:HyslopS JSJ | lld:pubmed |
| pubmed-article:8938450 | pubmed:author | pubmed-author:PitkänenSS | lld:pubmed |
| pubmed-article:8938450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8938450 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8938450 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8938450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8938450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8938450 | pubmed:pagination | 375-80 | lld:pubmed |
| pubmed-article:8938450 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
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| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:meshHeading | pubmed-meshheading:8938450-... | lld:pubmed |
| pubmed-article:8938450 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8938450 | pubmed:articleTitle | Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13. | lld:pubmed |
| pubmed-article:8938450 | pubmed:affiliation | Department of Biochemistry, University of Toronto, Canada. | lld:pubmed |
| pubmed-article:8938450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8938450 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8938450 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8938450 | lld:pubmed |
