| pubmed-article:8934541 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0008109 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0919528 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0598766 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0796367 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C1706395 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8934541 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8934541 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8934541 | pubmed:dateCreated | 1997-1-7 | lld:pubmed |
| pubmed-article:8934541 | pubmed:abstractText | 11q23 chromosome aberrations are frequently observed in infantile as well as therapy-related leukemias. The target gene at 11q23, MLL, is disrupted by the translocation and becomes fused to various translocation partner genes such as AF4/FEL, LTG9/AF9 and LTG19/ENL. The resulting chimeric mRNAs are fused in frame and have been predicted to encode leukemia-specific chimeric proteins. In the present study, we raised antibodies against MLL, LTG9 and LTG19 and demonstrated that MLL and chimeric MLL-LTG9 and MLL-LTG19 products are synthesized in vivo and are localized in the nuclei, using immunofluorescence and cell fractionation studies. The truncated N-terminal portion of the MLL product common to the various types of 11q23 translocation was also localized in the nuclei in a similar fashion. Murine 32Dc13 cells stably expressing the truncated N-terminal MLL protein exhibited an inhibition of differentiation and a growth advantage following stimulation by granulocyte-colony stimulating factor, although the IL-3 dependency was not significantly changed in comparison to the parental cells. These results suggest that the N-terminal portion common to various MLL-chimeric products plays an important role in leukemogenesis. | lld:pubmed |
| pubmed-article:8934541 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8934541 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8934541 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8934541 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8934541 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:TakahashiTT | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:SegawaTT | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:UedaRR | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:YamamotoKK | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:SetoMM | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:TakizawaJJ | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:JowEE | lld:pubmed |
| pubmed-article:8934541 | pubmed:author | pubmed-author:KagamiYY | lld:pubmed |
| pubmed-article:8934541 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8934541 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:8934541 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8934541 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8934541 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8934541 | pubmed:pagination | 1945-53 | lld:pubmed |
| pubmed-article:8934541 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:meshHeading | pubmed-meshheading:8934541-... | lld:pubmed |
| pubmed-article:8934541 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8934541 | pubmed:articleTitle | Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. | lld:pubmed |
| pubmed-article:8934541 | pubmed:affiliation | Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan. | lld:pubmed |
| pubmed-article:8934541 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8934541 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8934541 | lld:pubmed |
