| pubmed-article:8903853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8903853 | lifeskim:mentions | umls-concept:C0497327 | lld:lifeskim |
| pubmed-article:8903853 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8903853 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8903853 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:8903853 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:8903853 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8903853 | pubmed:dateCreated | 1997-3-6 | lld:pubmed |
| pubmed-article:8903853 | pubmed:abstractText | Previous studies in patients receiving interferon-alpha (IFN-alpha) therapy and patients with systemic lupus erythematosus have demonstrated that elevated cerebrospinal fluid (CSF) levels of IFN-alpha are associated with cognitive dysfunction. We measured IFN-alpha levels in CSF and blood by ELISA in human immunodeficiency virus (HIV)-positive patients with (n = 21) and without (n = 23) dementia and HIV-negative controls (n = 48). IFN-alpha was significantly elevated in the CSF of HIV-positive patients with dementia compared to those without dementia and controls. An increasing amount of IFN-alpha in the CSF was correlated with the clinical parameter of increasing Memorial Sloan Kettering scores; although these correlations were not statistically significant, they further suggest an association of increased CSF IFN-alpha with neurocognitive dysfunction in AIDS. Immunocytochemical staining of brains demonstrated IFN-alpha-positive macrophages and astrocytes in frontal cortex and white matter and IFN-alpha mRNA was detected by reverse transcriptase-polymerase chain reaction, further indicating that IFN-alpha is made by cells within the brain and suggesting that the significant increases of IFN-alpha protein found in the CSF of patients with HIV-associated dementia complex are derived from intrinsic brain cells such as macrophages and astrocytes. Increased local production of IFN-alpha during HIV infection may contribute directly or indirectly to the pathogenesis of HIV-associated dementia. | lld:pubmed |
| pubmed-article:8903853 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8903853 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8903853 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8903853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8903853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8903853 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8903853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8903853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8903853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8903853 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8903853 | pubmed:issn | 0889-1591 | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:FREDE BEB | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:GlassJ DJD | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:GriffinJJ | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:McArthurJ CJC | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:TyorW RWR | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:WesselinghSS | lld:pubmed |
| pubmed-article:8903853 | pubmed:author | pubmed-author:RhoM BMB | lld:pubmed |
| pubmed-article:8903853 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8903853 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8903853 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8903853 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8903853 | pubmed:pagination | 366-77 | lld:pubmed |
| pubmed-article:8903853 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8903853 | pubmed:meshHeading | pubmed-meshheading:8903853-... | lld:pubmed |
| pubmed-article:8903853 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8903853 | pubmed:articleTitle | A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia. | lld:pubmed |
| pubmed-article:8903853 | pubmed:affiliation | Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA. | lld:pubmed |
| pubmed-article:8903853 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8903853 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8903853 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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