| pubmed-article:8893833 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8893833 | lifeskim:mentions | umls-concept:C0008380 | lld:lifeskim |
| pubmed-article:8893833 | lifeskim:mentions | umls-concept:C0041942 | lld:lifeskim |
| pubmed-article:8893833 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:8893833 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:8893833 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:8893833 | pubmed:dateCreated | 1996-12-10 | lld:pubmed |
| pubmed-article:8893833 | pubmed:abstractText | A series of diaryl-substituted heterocyclic ureas was prepared, and their ability to inhibit acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and to lower plasma total cholesterol in cholesterol-fed animal models in vivo was examined. N-(2,6-Diisopropylphenyl)-N'-tetrazole or isoxazole-substituted heterocyclic ureas proved optimal. A carbon chain of 11-14 carbons substituted 1,3 with respect to the amine provided the optimal side chain. Substitution of the alkyl chain generally lowered activity. Tetrazole urea 2i dosed at 3 mg/kg lowered plasma total cholesterol (TC) 67% in an acute, cholesterol-fed (C-fed) rat model of hypercholesterolemia and 47% in C-fed dogs. Tetrazole 2i, dosed at 10 mg/kg, also lowered TC 52% and raised HDL cholesterol 113% in rats with pre-established hypercholesterolemia. | lld:pubmed |
| pubmed-article:8893833 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8893833 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8893833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8893833 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8893833 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8893833 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:EssenburgA... | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:WhiteA DAD | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:WilsonM WMW | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:KrauseB RBR | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:DominickM AMA | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:StanfieldR... | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:BousleyR FRF | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:BlankleyC JCJ | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:HamelehleK... | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:ChucholowskiA... | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:CreswellM WMW | lld:pubmed |
| pubmed-article:8893833 | pubmed:author | pubmed-author:NeubMM | lld:pubmed |
| pubmed-article:8893833 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8893833 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8893833 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8893833 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8893833 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8893833 | pubmed:pagination | 4382-95 | lld:pubmed |
| pubmed-article:8893833 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
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| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:meshHeading | pubmed-meshheading:8893833-... | lld:pubmed |
| pubmed-article:8893833 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8893833 | pubmed:articleTitle | Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. | lld:pubmed |
| pubmed-article:8893833 | pubmed:affiliation | Department of Medicinal Chemistry, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA. | lld:pubmed |
| pubmed-article:8893833 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:8893833 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8893833 | lld:pubmed |
