| pubmed-article:8892091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8892091 | lifeskim:mentions | umls-concept:C1705258 | lld:lifeskim |
| pubmed-article:8892091 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:8892091 | lifeskim:mentions | umls-concept:C0122040 | lld:lifeskim |
| pubmed-article:8892091 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:8892091 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8892091 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8892091 | pubmed:dateCreated | 1997-3-14 | lld:pubmed |
| pubmed-article:8892091 | pubmed:abstractText | Understanding the structural features of naturally processed peptides found within the major histocompatibility complex (MHC) class II peptide binding groove from disease-associated MHC molecules may provide insights into the nature of potential disease-related antigens. Class II MHC/peptide complexes were purified by immunoaffinity from transformed B cell lines homozygous for DRB1*0404 (an allele associated with rheumatoid arthritis) and *0402 (a closely related allele not associated with this disease). Peptides were eluted at acidic pH, fractionated by reversed phase HPLC, and analyzed by capillary electrophoresis. Those fractions containing a single dominant peptide were sequenced by automated Edman degradation and tandem mass spectrometry. The predominant peptide species identified came from non-polymorphic regions of the HLA class I molecules expressed by each cell line. Peptides from DRB1*0404 were found to be nested clusters derived from positions 26-43 of the HLA-B and -C alpha-chain. DRB1*0402 contained as the predominant peptide species a nested cluster from positions 129-145 of the HLA-B alpha-chain. The primary structure of the class I derived peptides was consistent with that seen by peptides exhibiting promiscuous DR binding behavior. Processing of MHC-derived peptides by MHC class II molecules is a common occurrence in the transformed B cell lines analyzed. | lld:pubmed |
| pubmed-article:8892091 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8892091 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8892091 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8892091 | pubmed:issn | 0360-4012 | lld:pubmed |
| pubmed-article:8892091 | pubmed:author | pubmed-author:YatesJ RJR3rd | lld:pubmed |
| pubmed-article:8892091 | pubmed:author | pubmed-author:McCormackA... | lld:pubmed |
| pubmed-article:8892091 | pubmed:author | pubmed-author:HaydenJ BJB | lld:pubmed |
| pubmed-article:8892091 | pubmed:author | pubmed-author:DaveyM PMP | lld:pubmed |
| pubmed-article:8892091 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8892091 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8892091 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8892091 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8892091 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8892091 | pubmed:pagination | 795-802 | lld:pubmed |
| pubmed-article:8892091 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:meshHeading | pubmed-meshheading:8892091-... | lld:pubmed |
| pubmed-article:8892091 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8892091 | pubmed:articleTitle | Analysis of naturally processed peptides eluted from HLA DRB1*0402 and *0404. | lld:pubmed |
| pubmed-article:8892091 | pubmed:affiliation | Department of Veterans Affairs Medical Center, Portland, OR 97207, USA. | lld:pubmed |
| pubmed-article:8892091 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8892091 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8892091 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8892091 | lld:pubmed |
