| pubmed-article:8871565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0085177 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C1420731 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0040287 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0220927 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8871565 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8871565 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:8871565 | pubmed:dateCreated | 1996-12-5 | lld:pubmed |
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| pubmed-article:8871565 | pubmed:abstractText | TIA-1 and TIAR are RNA binding proteins of the RNA recognition motif (RRM)/ribonucleoprotein (RNP) family that have been implicated as effectors of apoptotic cell death. We report the structures of murine TIA-1 and TIAR (mTIA-1 and mTIAR) deduced from cDNA cloning, the mRNA and protein tissue distribution of mTIA-1 and mTIAR, and the exon-intron structures of the mTIA-1 and mTIAR genes. Both mTIA-1 and mTIAR are comprised of three approximately 100 amino acid N-terminal RRM domains and a approximately 90 amino acid C-terminal auxiliary domain. This subfamily of RRM proteins is evolutionarily well conserved; mTIA-1 and mTIAR are 80% similar to each other, and 96 and 99% similar to hTIA-1 and hTIAR, respectively. The overall exon-intron structures of the mTIA-1 and mTIAR genes are also similar to each other, as well as to the human TIA-1 gene structure. While Northern blot analysis reveals that mTIA-1 and mTIAR mRNAs have a broad tissue distribution, mTIA-1 and mTIAR proteins are predominantly expressed in brain, testis and spleen. At least two isoforms of both mTIA-1 and mTIAR are generated by alternative splicing. Murine TIA-1 isoforms including or lacking the exon 5 encoded sequences are expressed at a ratio of approximately 1:1, whereas mTIAR isoforms including or lacking the 5'-end of exon 3 sequences are expressed in a approximately 1:6 ratio. Molecular characterization of murine TIA-1 and TIAR RNA binding proteins provides the basis for a genetic analysis of the functional roles of these proteins during mammalian development. | lld:pubmed |
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| pubmed-article:8871565 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8871565 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8871565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8871565 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8871565 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:8871565 | pubmed:author | pubmed-author:AndersonPP | lld:pubmed |
| pubmed-article:8871565 | pubmed:author | pubmed-author:O'BrienSS | lld:pubmed |
| pubmed-article:8871565 | pubmed:author | pubmed-author:CHENB TBT | lld:pubmed |
| pubmed-article:8871565 | pubmed:author | pubmed-author:StreuliMM | lld:pubmed |
| pubmed-article:8871565 | pubmed:author | pubmed-author:MedleyQ GQG | lld:pubmed |
| pubmed-article:8871565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8871565 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8871565 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:8871565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8871565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8871565 | pubmed:pagination | 3829-35 | lld:pubmed |
| pubmed-article:8871565 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8871565 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8871565 | pubmed:articleTitle | Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. | lld:pubmed |
| pubmed-article:8871565 | pubmed:affiliation | Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:8871565 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8871565 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8871565 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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