| pubmed-article:8864519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0018801 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0034052 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0027481 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:8864519 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:8864519 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8864519 | pubmed:dateCreated | 1997-1-6 | lld:pubmed |
| pubmed-article:8864519 | pubmed:abstractText | 1. Pacing-induced congestive heart failure (CHF) in dogs is associated with increased plasma levels of atrial natriuretic factor (ANF) and inhibition of receptor-mediated cyclic AMP-dependent relaxation in isolated pulmonary arteries (PA). Since ANF is known to be negatively coupled to adenylate cyclase, we studied cyclic AMP-mediated relaxation to isoprenaline (Iso) and arachidonic acid (AA) in PA from control dogs (C), dogs with pacing-induced CHF (CHF) and dogs with bilateral atrial appendectomy and CHF (ATR APP+CHF). 2. In CHF, plasma ANF levels increased from a baseline of 80 +/- 8 pg ml-1 to 283 +/- 64 pg ml-1 (P < 0.05), but the ATR APP+CHF group failed to show this increase (67 +/- 7 pg ml-1 vs 94 +/- 15 pg ml-1, P = NS). Plasma ANF levels, however, did not influence myocardial dysfunction in CHF. 3. The relaxation of 49 +/- 5% to 1 microM Iso in C was reduced to 23 +/- 4% in CHF (P < 0.05), but relaxation of 49 +/- 12% was observed in the ATR APP+CHF group (P = NS vs C). Relaxation responses to 10 microM AA were as follows: 77 +/- 5% (C, n = 8), 27 +/- 8% (CHF, n = 10, P < 0.05 vs C), and 93 +/- 5% (ATR APP+CHF, n = 5). The presence of CHF, or the plasma ANF levels, did not affect responses to cyclic GMP-mediated relaxing agents in PA. 4. These data indicate that the myocardial performance in CHF is not influenced by plasma ANF levels. However, altered cyclic AMP-mediated relaxation in PA during CHF is, in part, modulated by circulating ANF levels. | lld:pubmed |
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| pubmed-article:8864519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8864519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8864519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8864519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8864519 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8864519 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:WangJJ | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:MathewRR | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:GewitzM HMH | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:HintzeT HTH | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:ShenWW | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:WolinM SMS | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:OmarH AHA | lld:pubmed |
| pubmed-article:8864519 | pubmed:author | pubmed-author:FayngershRR | lld:pubmed |
| pubmed-article:8864519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8864519 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:8864519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8864519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8864519 | pubmed:pagination | 1886-90 | lld:pubmed |
| pubmed-article:8864519 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8864519 | pubmed:meshHeading | pubmed-meshheading:8864519-... | lld:pubmed |
| pubmed-article:8864519 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8864519 | pubmed:articleTitle | Modulation by atrial natriuretic factor of receptor-mediated cyclic AMP-dependent responses in canine pulmonary artery during heart failure. | lld:pubmed |
| pubmed-article:8864519 | pubmed:affiliation | Department of Paediatrics, New York Medical College, Valhalla 10595, USA. | lld:pubmed |
| pubmed-article:8864519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8864519 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8864519 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
