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pubmed-article:8839663pubmed:abstractTextTwo different conventional release enalapril maleate tablet formulations were evaluated for their relative bioavailability (Eupressin tablets 10 mg, Biosintética as the test formulation vs Renitec tablets 10 mg Merck Sharp & Dhome, as the reference formulation). A single 20 mg oral dose of each preparation was administered to 18 healthy male adult volunteers and their bioequivalence was assessed by comparing the serum enalaprilat and total enalapril (enalaprilat plus enalapril maleate) concentration-time curves. Angiotensin converting enzyme (ACE) activity was also quantified in each serum sample.lld:pubmed
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pubmed-article:8839663pubmed:articleTitleBioequivalence study of two enalapril maleate tablet formulations in healthy male volunteers. Pharmacokinetic versus pharmacodynamic approach.lld:pubmed
pubmed-article:8839663pubmed:affiliationMiguel Servet Clinical Pharmacology Unit, Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil.lld:pubmed
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