| pubmed-article:8812145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0908936 | lld:lifeskim |
| pubmed-article:8812145 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8812145 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8812145 | pubmed:dateCreated | 1996-12-10 | lld:pubmed |
| pubmed-article:8812145 | pubmed:abstractText | Extracellular matrix molecules, including laminin, affect the development of enteric neurons and accumulate in the aganglionic colon of ls/ls mice. Quantitative Northern analysis revealed that mRNAs encoding the beta 1 and gamma 1 subunits of laminin and collagens alpha 1(IV) and alpha 2(IV) are increased in the colons of ls/ls mice. Transcripts of laminin alpha 1 were evaluated quantitatively with reverse transcription and the competitive polymerase chain reaction (RT-cPCR). The abundance of laminin alpha 1 transcripts was developmentally regulated, but greater in the ls/ls than the wild-type colon at each age examined. In situ hybridization revealed that transcripts in the colon encoding laminin alpha 1 and beta 1 and collagen alpha 2(IV) were initially expressed in the endoderm, but by E15, expression shifted to cells of the colonic mesenchyme (ls/ls > wild type) where crest-derived cells migrate. The expression of laminin alpha 1 was examined in the totally aganglionic intestine of E15 and newborn c-ret -/- mice, to determine whether an increase occurs when neurogenesis fails independently of the ls/ls defect. RT-cPCR revealed no difference from control in mRNA encoding laminin alpha 1 in the c-ret -/- colon in either E15 or newborn animals. The accumulation of immunohistochemically demonstrable laminin that is prominent in the newborn ls/ls colon could not be detected in that of c-ret -/- animals. These observations suggest that transcripts encoding laminin-1 and collagen (IV) are increased in the colon and surrounding pelvic mesenchyme of ls/ls mice because of an intrinsic lesion, rather than a secondary consequence of aganglionosis. The data are compatible with the hypothesis that the increased expression of laminin-1 contributes to the failure of crest-derived cells to complete their colonization of the ls/ls colon. | lld:pubmed |
| pubmed-article:8812145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8812145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8812145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8812145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8812145 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8812145 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:GershonM DMD | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:RothmanT PTP | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:ChenJJ | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:HowardM JMJ | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:CostantiniFF | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:PachnisVV | lld:pubmed |
| pubmed-article:8812145 | pubmed:author | pubmed-author:SchuchardtAA | lld:pubmed |
| pubmed-article:8812145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8812145 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8812145 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:8812145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8812145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8812145 | pubmed:pagination | 498-513 | lld:pubmed |
| pubmed-article:8812145 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8812145 | pubmed:meshHeading | pubmed-meshheading:8812145-... | lld:pubmed |
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| pubmed-article:8812145 | pubmed:meshHeading | pubmed-meshheading:8812145-... | lld:pubmed |
| pubmed-article:8812145 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8812145 | pubmed:articleTitle | Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret -/- mice. | lld:pubmed |
| pubmed-article:8812145 | pubmed:affiliation | Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:8812145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8812145 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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