| pubmed-article:8791828 | pubmed:abstractText | Some 2, 3, 6-trisubstituted quinoxaline derivatives were synthesized and their antispasmodic activities were determined on the isolated rat ileum. In the synthesis, some dicarbonyl compounds were reacted with substituted or non-substituted o-phenylenediamines in the presence of acetic acid and gained eighteen compounds. All spectral and elemental analyses of the compounds complete and their structures were elucidated. The pharmacological experiments indicate that the compounds 12,13,18 were most active derivatives and their LD50 values were found to be greater than 100 mg/kg (i.p.). | lld:pubmed |
